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1,2-Dichloroethane (107-06-2)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Positive, Male, Rats
View
  • Positive, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Positive, Male, Mice
View
  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 1,2-Dichloroethane (107-06-2).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 1,2-Dichloroethane (107-06-2).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 1,2-Dichloroethane (107-06-2).
Bacterial Mutagenicity
View
  • Positive

Citation Information


NTP. 1,2-Dichloroethane (107-06-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-055 Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity (CASRN 107-06-2)
TOX-04 Toxicity Studies of 1,2-Dichloroethane (Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-Mendel Rats, and B6C3F1Mice (Drinking Water and Gavage Studies) (CASRN 107-06-2)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194

Study Data


Toxicity and Carcinogenicity Studies


3-Month Evaluation of the Toxicity (C00511B) of 1,2-Dichloroethane (107-06-2) in F344/N Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C00511C) of 1,2-Dichloroethane (107-06-2) in F344/N Rats Exposed via Dosed Water
3-Month Evaluation of the Toxicity (C00511D) of 1,2-Dichloroethane (107-06-2) in F344/N Rats Exposed via Dosed Water
3-Month Evaluation of the Toxicity (C00511D) of 1,2-Dichloroethane (107-06-2) in Osborne-Mendel Rats Exposed via Dosed Water
3-Month Evaluation of the Toxicity (C00511C) of 1,2-Dichloroethane (107-06-2) in B6C3F1 Mice Exposed via Dosed Water
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dichloroethane (107-06-2) in Male Osborne-Mendel Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dichloroethane (107-06-2) in Female Osborne-Mendel Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dichloroethane (107-06-2) in Male B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dichloroethane (107-06-2) in Female B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 1,2-Dichloroethane (107-06-2) in Micronucleus Study A32670 in B6C3F1 Mice
Genetic Toxicity Evaluation of 1,2-Dichloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 446462
Summary Data