TR-587: Tetrabromobisphenol A (79-94-7)

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View Clear Evidence, Female, Rats Equivocal Evidence, Male, Rats

An overview of chronic evidence from Mice studies.
Mice
View No Evidence, Female, Mice Some Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to TR-587: Tetrabromobisphenol A (79-94-7).
Micronucleus - Mice
View Male: Negative Female: Negative

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TR-587: Tetrabromobisphenol A (79-94-7).
Bacterial Mutagenicity
View Negative
View Negative

Citation Information

NTP. TR-587: Tetrabromobisphenol A (79-94-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

TR-587 Toxicology Studies of Tetrabromobisphenol A (CASRN 79-94-7) in F344/NTac Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Tetrabromobisphenol A in Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice (Gavage Studies)

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Data

3-Month Evaluation of the Toxicity (C20320) of Tetrabromobisphenol A (79-94-7) in F344/NTac Rats Exposed via Gavage

Study Tables

E03 - Growth Curves (768 kB)
E04 - Mean Body Weights and Survival Table (57 kB)
E05 - Clinical Observations Summary (56 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (113 kB)
P04 - Neoplasms by Individual Animal (1 mB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (149 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (1 mB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (108 kB)
P14 - Individual Animal Pathology Data (263 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (118 kB)
P40 - Survival Curves (816 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (35 kB)
Female Individual Animal Clinical Observations (4 kB)
Female Individual Animal Non Neoplastic Pathology Data (43 kB)
Female Individual Animal Organ Weight Data (19 kB)
Female Individual Animal Survival Data (11 kB)
Male Individual Animal Body Weight Data (35 kB)
Male Individual Animal Clinical Observations (3 kB)
Male Individual Animal Neoplastic Pathology Data (2 kB)
Male Individual Animal Non Neoplastic Pathology Data (45 kB)
Male Individual Animal Organ Weight Data (19 kB)
Male Individual Animal Survival Data (11 kB)

Data

3-Month Evaluation of the Toxicity (C20320) of Tetrabromobisphenol A (79-94-7) in B6C3F1/N Mice Exposed via Gavage

Study Tables

E03 - Growth Curves (749 kB)
E04 - Mean Body Weights and Survival Table (184 kB)
E05 - Clinical Observations Summary (24 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (69 kB)
P04 - Neoplasms by Individual Animal (1 mB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (94 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (1 mB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (46 kB)
P14 - Individual Animal Pathology Data (1 mB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (90 kB)
P40 - Survival Curves (811 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (34 kB)
Female Individual Animal Non Neoplastic Pathology Data (5 kB)
Female Individual Animal Organ Weight Data (19 kB)
Female Individual Animal Survival Data (11 kB)
Male Individual Animal Body Weight Data (34 kB)
Male Individual Animal Non Neoplastic Pathology Data (14 kB)
Male Individual Animal Organ Weight Data (19 kB)
Male Individual Animal Survival Data (11 kB)

Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C20320) of Tetrabromobisphenol A (79-94-7) in Wistar Han Rats Exposed via Gavage

Study Tables

E03 - Growth Curves (70 kB)
E04 - Mean Body Weights and Survival Table (24 kB)
E05 - Clinical Observations Summary (22 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (54 kB)
P04 - Neoplasms by Individual Animal (624 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (49 kB)
P08 - Statistical Analysis of Primary Tumors (208 kB)
P08 – Statistical Analysis of Primary Tumors of the Extended Uterine Evaluation (114 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (751 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (349 kB)
P10 – Statistical Analysis of Non-neoplastic Lesions of the Extended Uterine Evaluation (119 kB)
P11 - Statistical Analysis of Survival Data (24 kB)
P14 - Individual Animal Pathology Data (1 mB)
P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (598 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (56 kB)
P40 - Survival Curves (66 kB)
TBBPA Uterine Pathology in the Rats (426 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (441 kB)
Female Individual Animal Clinical Observations (132 kB)
Female Individual Animal Neoplastic Pathology Data (110 kB)
Female Individual Animal Non Neoplastic Pathology Data (501 kB)
Female Individual Animal Organ Weight Data (63 kB)
Female Individual Animal Survival Data (37 kB)
Male Individual Animal Body Weight Data (406 kB)
Male Individual Animal Clinical Observations (105 kB)
Male Individual Animal Neoplastic Pathology Data (82 kB)
Male Individual Animal Non Neoplastic Pathology Data (550 kB)
Male Individual Animal Organ Weight Data (63 kB)
Male Individual Animal Survival Data (37 kB)

Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C20320) of Tetrabromobisphenol A (79-94-7) in B6C3F1 Mice Exposed via Gavage

Study Tables

E03 - Growth Curves (67 kB)
E04 - Mean Body Weights and Survival Table (24 kB)
E05 - Clinical Observations Summary (20 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (54 kB)
P04 - Neoplasms by Individual Animal (651 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (48 kB)
P08 - Statistical Analysis of Primary Tumors (193 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (762 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (324 kB)
P11 - Statistical Analysis of Survival Data (24 kB)
P14 - Individual Animal Pathology Data (1 mB)
P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (587 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (56 kB)
P40 - Survival Curves (67 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (448 kB)
Female Individual Animal Clinical Observations (29 kB)
Female Individual Animal Neoplastic Pathology Data (79 kB)
Female Individual Animal Non Neoplastic Pathology Data (366 kB)
Female Individual Animal Organ Weight Data (57 kB)
Female Individual Animal Survival Data (34 kB)
Male Individual Animal Body Weight Data (427 kB)
Male Individual Animal Clinical Observations (71 kB)
Male Individual Animal Neoplastic Pathology Data (144 kB)
Male Individual Animal Non Neoplastic Pathology Data (468 kB)
Male Individual Animal Organ Weight Data (57 kB)
Male Individual Animal Survival Data (34 kB)

Protocol

Genetic Toxicology Studies

Data

Genetic Toxicity Evaluation of Tetrabromobisphenol A (79-94-7) in Micronucleus Study A13260 in B6C3F1 Mice

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (69 KB)
Individual Animal In Vivo Micronucleus Data (9 KB)

Data

Genetic Toxicity Evaluation of Tetrabromobisphenol A in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 968573

Summary Data

G06 - Ames Summary Data (138 KB)

Data

Genetic Toxicity Evaluation of Tetrabromobisphenol A in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G20033

Summary Data

G06 - Ames Summary Data (80 KB)

TR-587: Tetrabromobisphenol A (79-94-7)

Study Results

Chronic Bioassay Level of Evidence

Genetic Toxicology

Citation Information

Related Links

Publications

Study Data

Toxicity and Carcinogenicity Studies

3-Month Evaluation of the Toxicity (C20320) of Tetrabromobisphenol A (79-94-7) in F344/NTac Rats Exposed via Gavage

Study Tables

Individual Animal Data

3-Month Evaluation of the Toxicity (C20320) of Tetrabromobisphenol A (79-94-7) in B6C3F1/N Mice Exposed via Gavage

Study Tables

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C20320) of Tetrabromobisphenol A (79-94-7) in Wistar Han Rats Exposed via Gavage

Study Tables

Individual Animal Data

Evaluation of the Chronic Toxicity and Carcinogenicity (C20320) of Tetrabromobisphenol A (79-94-7) in B6C3F1 Mice Exposed via Gavage

Study Tables

Individual Animal Data

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Tetrabromobisphenol A (79-94-7) in Micronucleus Study A13260 in B6C3F1 Mice

Summary and Individual Animal Data

Genetic Toxicity Evaluation of Tetrabromobisphenol A in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 968573

Summary Data

Genetic Toxicity Evaluation of Tetrabromobisphenol A in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G20033

Summary Data