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TR-581: Cobalt (7440-48-4)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Clear Evidence, Female, Rats
  • Clear Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to TR-581: Cobalt (7440-48-4).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TR-581: Cobalt (7440-48-4).
Bacterial Mutagenicity
View
  • Positive

Citation Information


NTP. TR-581: Cobalt (7440-48-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2020-08-09. https://manticore.niehs.nih.gov/cebssearch/publication/TR-581

Publications


TR-581 Toxicology Studies of Cobalt Metal (CASRN 7440-48-4) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Cobalt Metal in F344/NTac Rats and B6C3F1/N Mice (Inhalation Studies)

Study Data


Toxicity and Carcinogenicity Studies


2-Week Evaluation of the Toxicity (C60311) of Cobalt (7440-48-4) in F344/N Rats via Whole Body Respiratory Exposure
2-Week Evaluation of the Toxicity (C60311) of Cobalt (7440-48-4) in B6C3F1 Mice via Whole Body Respiratory Exposure
3-Month Evaluation of the Toxicity (C60311) of Cobalt (7440-48-4) in F344/N Rats via Whole Body Respiratory Exposure
3-Month Evaluation of the Toxicity (C60311) of Cobalt (7440-48-4) in B6C3F1 Mice via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity (C60311) of Cobalt (7440-48-4) in F344/NTac Rats via Whole Body Respiratory Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity (C60311) of Cobalt (7440-48-4) in B6C3F1 Mice via Whole Body Respiratory Exposure

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Cobalt (7440-48-4) in Micronucleus Study A57655 in B6C3F1 Mice
Genetic Toxicity Evaluation of Cobalt in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A79569
Summary Data