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TR-469: Interferon AD + 3'-azido-3'-deoxythymidine (AIDS Initiative) (INTAZTCOMB), 3'-Azido-3'-deoxythymidine (30516-87-1), Interferon A (76543-88-9)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Mice studies.
Mice
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  • Clear Evidence, Female, Mice
  • Equivocal Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus study conclusions related to TR-469: Interferon AD + 3'-azido-3'-deoxythymidine (AIDS Initiative) (INTAZTCOMB), 3'-Azido-3'-deoxythymidine (30516-87-1), Interferon A (76543-88-9).
Micronucleus - Mice
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  • Male: Positive
View
  • Male: Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to TR-469: Interferon AD + 3'-azido-3'-deoxythymidine (AIDS Initiative) (INTAZTCOMB), 3'-Azido-3'-deoxythymidine (30516-87-1), Interferon A (76543-88-9).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TR-469: Interferon AD + 3'-azido-3'-deoxythymidine (AIDS Initiative) (INTAZTCOMB), 3'-Azido-3'-deoxythymidine (30516-87-1), Interferon A (76543-88-9).
Bacterial Mutagenicity
View
  • Positive

Citation Information


NTP. TR-469: Interferon AD + 3'-azido-3'-deoxythymidine (AIDS Initiative) (INTAZTCOMB), 3'-Azido-3'-deoxythymidine (30516-87-1), Interferon A (76543-88-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2020-01-27. https://manticore.niehs.nih.gov/cebssearch/publication/TR-469

Publications


TR-469 Toxicology and Carcinogenesis Studies of AZT (CASRN 30516-87-1) and AZT/ a-Interferon A/D B6C3F1 Mice (Gavage Studies)

Study Data


Toxicity and Carcinogenicity Studies


18-33 Day Evaluation of the Toxicity (C89006) of Interferon AD + 3'-Azido-3'-deoxythymidine (AIDS Initiative) (INTAZTCOMB) in B6C3F1 Mice Exposed via Subcutaneous Injection
3-Month Evaluation of the Toxicity (C88072) of 3'-Azido-3'-deoxythymidine (AIDS) (30516-87-1) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C88072) of 3'-Azido-3'-deoxythymidine (AIDS) (30516-87-1) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C89001) of Interferon A (AIDS Initiative) (76543-88-9) in B6C3F1 Mice Exposed via Subcutaneous Injection
Evaluation of the Chronic Toxicity and Carcinogenicity (C89006) of Interferon AD + 3'-Azido-3'-deoxythymidine (AIDS Initiative) (INTAZTCOMB) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C89006) of Interferon AD + 3'-Azido-3'-deoxythymidine (AIDS Initiative) (INTAZTCOMB) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C89006) of Interferon AD + 3'-Azido-3'-deoxythymidine (AIDS Initiative) (INTAZTCOMB) in B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AIDS) (30516-87-1) in Micronucleus Study 912603 in B6C3F1 Mice
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AIDS) (30516-87-1) in Micronucleus Study A88072 in B6C3F1 Mice
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AIDS) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 860655