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Study Information
Study Attribute Value
CEBS Accession Number: 002-03148-0001-0000-9
Chemical Name: p,p'-Dichlorodiphenyl sulfone
CASRN: 80-07-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 133717_SCE
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Questionable 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/05/1991    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1048 366 0.349 7.32 26.0 0.741
Dimethyl Sulfoxide 
0         
 50 1050 364 0.347 7.28 26.0 0.000
Test Chemical p,p'-Dichlorodiphenyl sulfone 
20         
 50 1049 367 0.350 7.34 26.0 0.920 
67         
 50 1048 393 0.375 7.86 26.0 8.173 
200         
 50 1046 432 0.413 8.64 26.0 19.135 
667         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 484 0.461 9.68 26.0 32.967
Mitomycin-C 
 0.004     
 10 208 240 1.154 24.00 26.0 232.840
Trend: 2.650        
Probability: 0.004        

Trial #: 2    Activation: No Activation    Date: 06/20/1991    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 404 0.385 8.08 31.0 0.000
Dimethyl Sulfoxide 
0         
 50 1050 387 0.369 7.74 26.0 -4.208
Test Chemical p,p'-Dichlorodiphenyl sulfone 
200         
 50 1049 418 0.398 8.36 31.0 3.564 
250         
 50 1050 444 0.423 8.88 31.0 9.901 
300         
 50 1045 468 0.448 9.36 31.0 16.396
Positive Control Mitomycin-C 
 0.001     
 50 1049 522 0.498 10.44 26.0 29.331
Mitomycin-C 
 0.004     
 10 210 256 1.219 25.60 26.0 216.832
Trend: 2.400        
Probability: 0.008        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/05/1991    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 358 0.341 7.16 26.0 0.471
Dimethyl Sulfoxide 
0         
 50 1051 357 0.340 7.14 26.0 0.000
Test Chemical p,p'-Dichlorodiphenyl sulfone 
6.7       
 50 1050 364 0.347 7.28 26.0 2.058 
20         
 50 1044 365 0.350 7.30 26.0 2.926 
667         
 50 1050 383 0.365 7.66 26.0 7.385 
2000         
 50 1049 416 0.397 8.32 26.0 16.749
Positive Control Cyclophosphamide 
 0.125     
 50 1048 551 0.526 11.02 26.0 54.784
Cyclophosphamide 
 0.5       
 10 210 188 0.895 18.80 26.0 163.556
Trend: 2.232        
Probability: 0.013