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Study Information
Study Attribute Value
CEBS Accession Number: 002-02981-0002-0000-4
Chemical Name: Trisodium ethylenediaminetetraacetate trihydrate (EDTA)
CASRN: 150-38-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 215387_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 10/17/1984    Harvest Time: 13.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Trisodium ethylenediaminetetraacetate trihydrate (EDTA)
25         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
50         
100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
75         
100 5 0.050 5.0 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0
100         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.25      
100 29 0.290 26.0 24 0.240 22.0 5 0.050 5.0 0 0.000 0.0
Mitomycin-C
1         
50 31 0.620 46.0 24 0.480 44.0 7 0.140 14.0 0 0.000 0.0
Trend: 1.106 1.331 0.333  
Probability: 0.134 0.092 0.370  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/31/1984    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Trisodium ethylenediaminetetraacetate trihydrate (EDTA)
25         
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
50         
100 4 0.040 4.0 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0
75         
100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
100         
100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide
15         
100 55 0.550 40.0 29 0.290 22.0 26 0.260 22.0 0 0.000 0.0
Trend: 0.686 -0.156 1.164  
Probability: 0.247 0.562 0.122