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Study Information
Study Attribute Value
CEBS Accession Number: 002-02970-0002-0000-2
Chemical Name: Trimethylphosphate
CASRN: 512-56-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 445223_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Positive 
Induced Rat Liver S9  1_S9  Negative 
No Activation  Positive 

Trial #:1   Activation: No Activation    Date: 06/10/1986    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Medium
0         
200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Trimethylphosphate
1600         
200 6 0.030 3.0 0 0.000 0.0 6 0.030 3.0 0 0.000 0.0
3000         
200 17 0.085 7.5 5 0.025 2.5 12 0.060 6.0 0 0.000 0.0
5000         
200 28 0.140 14.0 17 0.085 8.5 11 0.055 5.5 0 0.000 0.0
Positive Control: Mitomycin-C
 0.0625    
200 38 0.190 17.0 12 0.060 6.0 26 0.130 12.0 0 0.000 0.0
Mitomycin-C
 0.25      
50 23 0.460 38.0 10 0.200 18.0 13 0.260 24.0 0 0.000 0.0
Trend: 5.848 5.345 3.040  
Probability: 0.000 0.000 0.001  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/10/1986    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Medium
0         
200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Trimethylphosphate
1600         
200 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 0 0.000 0.0
3000         
200 3 0.015 1.0 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
5000         
200 8 0.040 3.5 1 0.005 0.5 7 0.035 3.5 0 0.000 0.0
Positive Control: Cyclophosphamide
2.5       
200 27 0.135 12.0 7 0.035 3.5 20 0.100 9.5 0 0.000 0.0
Cyclophosphamide
7.5       
50 37 0.740 30.0 3 0.060 4.0 14 0.280 26.0 20 0.400 2.0
Trend: 1.823 0.443 2.262  
Probability: 0.034 0.329 0.012  


Trial #:2   Activation: No Activation    Date: 08/13/1986    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Medium
0         
200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: Trimethylphosphate
1600         
200 9 0.045 4.0 1 0.005 0.5 8 0.040 3.5 0 0.000 0.0
3000         
200 16 0.080 7.0 4 0.020 2.0 12 0.060 5.5 0 0.000 0.0
5000         
200 24 0.120 11.5 5 0.025 2.5 19 0.095 9.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.0625    
200 28 0.140 13.0 12 0.060 6.0 16 0.080 7.5 0 0.000 0.0
Mitomycin-C
 0.125     
50 24 0.480 26.0 7 0.140 6.0 17 0.340 24.0 0 0.000 0.0
Trend: 4.373 2.577 3.577  
Probability: 0.000 0.005 0.000