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Study Information
Study Attribute Value
CEBS Accession Number: 002-02970-0001-0000-1
Chemical Name: Trimethylphosphate
CASRN: 512-56-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 445223_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 02/18/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1049 359 0.342 7.18 26.0 0.000
Test Chemical Trimethylphosphate 
50         
 50 1046 550 0.526 11.00 26.0 53.643 
160         
 50 1048 753 0.719 15.06 26.0 109.949 
500         
 50 1048 1186 1.132 23.72 26.0 230.677 
1600         
 10 212 586 2.764 58.60 26.0 707.686 
5000         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 506 0.483 10.12 26.0 41.082
Mitomycin-C 
 0.005     
 10 210 333 1.586 33.30 26.0 363.347
Trend: 33.619        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 03/18/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1050 384 0.366 7.68 26.0 0.000
Test Chemical Trimethylphosphate 
50         
 50 1049 489 0.466 9.78 26.0 27.465 
160         
 50 1052 660 0.627 13.20 26.0 71.548 
500         
 50 1050 1006 0.958 20.12 26.0 161.979 
1600         
 10 210 589 2.805 58.90 26.0 666.927
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 540 0.515 10.80 26.0 40.759
Mitomycin-C 
 0.005     
 10 210 361 1.719 36.10 26.0 370.052
Trend: 31.191        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/06/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1049 427 0.407 8.54 26.0 0.000
Test Chemical Trimethylphosphate 
160         
 50 1051 504 0.480 10.08 26.0 17.808 
500         
 50 1046 538 0.514 10.76 26.0 26.357 
1600         
 50 1053 691 0.656 13.82 26.0 61.212 
5000         
 50 1046 961 0.919 19.22 26.0 125.704
Positive Control Cyclophosphamide 
 0.1       
 50 1037 611 0.589 12.22 26.0 44.747
Cyclophosphamide 
 0.6       
 10 212 269 1.269 26.90 26.0 211.720
Trend: 15.921        
Probability: 0.000