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Study Information
Study Attribute Value
CEBS Accession Number: 002-02930-0001-0000-7
Chemical Name: Triallyl isocyanurate
CASRN: 1025-15-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 652546_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Weakly Positive 
No Activation  Test Failure 
No Activation  Negative 
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 05/13/1986    Trial Call: Weakly Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1047 469 0.448 9.38 26.5 0.000
Test Chemical Triallyl isocyanurate
29.7       
50 1050 544 0.518 10.88 26.5 15.660
99         
50 1047 582 0.556 11.64 26.5 24.094
297         
50 1052 540 0.513 10.80 26.5 14.591
990         
0 0 0 0.000 0.00 26.5 N/A
Positive Control Mitomycin-C
 0.0015    
50 1046 625 0.598 12.50 26.5 33.390
Mitomycin-C
 0.01      
10 210 319 1.519 31.90 26.5 239.114
Trend: 2.410        
Probability: 0.008        

Trial #: 2    Activation: No Activation    Date: 06/18/1986    Trial Call: Test Failure   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1045 476 0.456 9.52 26.5 0.000
Test Chemical Triallyl isocyanurate
205         
50 1048 492 0.469 9.84 26.5 3.065
410         
50 1047 506 0.483 10.12 26.5 6.099
615         
50 1044 538 0.515 10.76 26.5 13.133
820         
0 0 0 0.000 0.00 30.5 N/A
Positive Control Mitomycin-C
 0.0015    
100 2074 1101 0.531 11.01 26.5 16.543
Mitomycin-C
 0.01      
10 210 182 0.867 18.20 26.5 90.266
Trend: 1.976        
Probability: 0.024        

Trial #: 3    Activation: No Activation    Date: 09/03/1986    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1030 472 0.458 9.44 26.5 0.000
Test Chemical Triallyl isocyanurate
403         
50 1038 474 0.457 9.48 26.5 -0.350
505         
50 1040 525 0.505 10.50 26.5 10.159
605         
50 1038 482 0.464 9.64 26.5 1.332
705         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C
 0.0E-4    
50 1028 879 0.855 17.58 26.5 86.591
Mitomycin-C
 0.01      
10 212 763 3.599 76.30 26.5 685.387
Trend: 0.763        
Probability: 0.223        

Trial #: 4    Activation: No Activation    Date: 03/03/1988    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1039 388 0.373 7.76 26.5 0.000
Test Chemical Triallyl isocyanurate
50.5       
50 1037 310 0.299 6.20 26.5 -19.949
101         
50 1028 356 0.346 7.12 26.5 -7.266
201         
50 1026 335 0.327 6.70 26.5 -12.566
Positive Control Mitomycin-C
 0.0015    
50 1040 696 0.669 13.92 26.5 79.209
Mitomycin-C
 0.01      
10 207 498 2.406 49.80 26.5 544.233
Trend: -1.161        
Probability: 0.877        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/20/1986    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1042 432 0.415 8.64 26.0 0.000
Test Chemical Triallyl isocyanurate
29.1       
50 1049 461 0.439 9.22 26.0 6.001
97         
50 1045 509 0.487 10.18 26.0 17.486
291         
50 1047 486 0.464 9.72 26.0 11.963
970         
0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide
 0.5       
50 1047 638 0.609 12.76 26.0 46.980
Cyclophosphamide
2.5       
10 210 295 1.405 29.50 26.0 238.834
Trend: 2.139        
Probability: 0.016