Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02844-0002-0000-2 |
Chemical Name: | Styrene |
CASRN: | 100-42-5 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 987609_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Test Failure |
Induced Rat Liver S9 | 1_S9 | Negative |
No Activation | 2 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 5 | 0.025 | 2.0 | 3 | 0.015 | 1.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Styrene | 151 | 200 | 4 | 0.020 | 2.0 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Positive Control: | Mitomycin-C | 0.75 | 25 | 13 | 0.520 | 36.0 | 5 | 0.200 | 20.0 | 8 | 0.320 | 24.0 | 0 | 0.000 | 0.0 |
Trend: | 0.000 | 0.000 | 0.000 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 4 | 0.020 | 1.5 | 0 | 0.000 | 0.0 | 4 | 0.020 | 1.5 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 5 | 0.025 | 1.5 | 1 | 0.005 | 0.5 | 4 | 0.020 | 1.5 | 0 | 0.000 | 0.0 | |
Test Chemical: | Styrene | 37.4 | 200 | 7 | 0.035 | 3.5 | 5 | 0.025 | 2.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
74.8 | 200 | 4 | 0.020 | 1.5 | 2 | 0.010 | 1.0 | 2 | 0.010 | 0.5 | 0 | 0.000 | 0.0 | ||
113.3 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
151 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 7.5 | 200 | 37 | 0.185 | 11.5 | 5 | 0.025 | 2.5 | 22 | 0.110 | 9.0 | 10 | 0.050 | 0.5 |
Cyclophosphamide | 37.5 | 25 | 14 | 0.560 | 40.0 | 5 | 0.200 | 16.0 | 9 | 0.360 | 28.0 | 0 | 0.000 | 0.0 | |
Trend: | -0.905 | -0.539 | -1.207 | ||||||||||||
Probability: | 0.817 | 0.705 | 0.886 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Styrene | 22.4 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
29.9 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
74.8 | 200 | 5 | 0.025 | 2.5 | 1 | 0.005 | 0.5 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
149.5 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.25 | 200 | 37 | 0.185 | 13.5 | 17 | 0.085 | 8.0 | 20 | 0.100 | 8.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.75 | 25 | 11 | 0.440 | 24.0 | 6 | 0.240 | 12.0 | 5 | 0.200 | 16.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.933 | -0.064 | 1.112 | ||||||||||||
Probability: | 0.175 | 0.526 | 0.133 |