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Study Information
Study Attribute Value
CEBS Accession Number: 002-02795-0002-0000-7
Chemical Name: Scopolamine hydrobromide trihydrate
CASRN: 6533-68-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 243331_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive* 
Induced Rat Liver S9  2_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 09/24/1986    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Scopolamine hydrobromide trihydrate 
1000         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
1600         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
3000         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 40 0.200 16.0 16 0.080 6.0 24 0.120 11.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 17 0.340 30.0 13 0.260 22.0 4 0.080 8.0 0 0.000 0.0
Trend: -0.398 0.000 -0.398  
Probability: 0.655 0.000 0.655  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/19/1988    Harvest Time: 13 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Scopolamine hydrobromide trihydrate 
1600         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
3000         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
5000         
 200 28 0.140 11.0 2 0.010 1.0 26 0.130 10.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 28 0.140 12.0 3 0.015 1.5 25 0.125 11.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 17 0.340 34.0 3 0.060 6.0 14 0.280 28.0 0 0.000 0.0
Trend: 5.188 1.240 5.209  
Probability: 0.000 0.108 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 10/21/1986    Harvest Time: 13.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: Scopolamine hydrobromide trihydrate 
1600         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
3000         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
5000         
 200 12 0.060 6.0 1 0.005 0.5 11 0.055 5.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 35 0.175 15.0 7 0.035 3.0 28 0.140 12.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 23 0.460 36.0 8 0.160 14.0 15 0.300 26.0 0 0.000 0.0
Trend: 3.320 0.269 3.508  
Probability: 0.000 0.394 0.000