COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02795-0001-0000-6
Chemical Name: Scopolamine hydrobromide trihydrate
CASRN: 6533-68-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 243331_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 
Induced Rat Liver S9  3_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/29/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 381 0.363 7.62 26.0 0.000
Test Chemical Scopolamine hydrobromide trihydrate 
16         
 50 1048 401 0.383 8.02 26.0 5.350 
50         
 50 1048 420 0.401 8.40 26.0 10.341 
160         
 50 1051 401 0.382 8.02 26.0 5.049 
500         
 50 1050 405 0.386 8.10 26.0 6.198
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 511 0.487 10.22 26.0 34.121
Mitomycin-C 
 0.005     
 10 210 287 1.367 28.70 26.0 276.282
Trend: 0.724        
Probability: 0.234        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/29/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 368 0.351 7.36 26.0 0.000
Test Chemical Scopolamine hydrobromide trihydrate 
160         
 50 1050 394 0.375 7.88 26.0 6.963 
500         
 50 1049 407 0.388 8.14 26.0 10.598 
1600         
 50 1050 401 0.382 8.02 26.0 8.864 
5000         
 50 1047 471 0.450 9.42 26.0 28.234
Positive Control Cyclophosphamide 
 0.1       
 50 1049 466 0.444 9.32 26.0 26.630
Cyclophosphamide 
 0.6       
 10 210 228 1.086 22.80 26.0 209.488
Trend: 3.356        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 10/15/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1047 410 0.392 8.20 26.0 0.000
Test Chemical Scopolamine hydrobromide trihydrate 
2000         
 50 1048 539 0.514 10.78 26.0 31.338 
3000         
 50 1050 524 0.499 10.48 26.0 27.440 
4000         
 50 1050 556 0.530 11.12 26.0 35.222 
5000         
 50 1049 582 0.555 11.64 26.0 41.681
Positive Control Cyclophosphamide 
 0.1       
 50 1049 576 0.549 11.52 26.0 40.220
Cyclophosphamide 
 0.6       
 10 210 247 1.176 24.70 26.0 200.359
Trend: 4.928        
Probability: 0.000        

Trial #: 3_S9    Activation: Induced Rat Liver S9    Date: 12/08/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1050 410 0.390 8.20 26.0 0.000
Test Chemical Scopolamine hydrobromide trihydrate 
2000         
 50 1048 479 0.457 9.58 26.0 17.052 
3000         
 50 1050 454 0.432 9.08 26.0 10.732 
4000         
 50 1049 427 0.407 8.54 26.0 4.246 
5000         
 50 1051 477 0.454 9.54 26.0 16.231
Positive Control Cyclophosphamide 
 0.1       
 50 1049 530 0.505 10.60 26.0 29.392
Cyclophosphamide 
 0.6       
 10 211 237 1.123 23.70 26.0 187.655
Trend: 1.101        
Probability: 0.135