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Study Information
Study Attribute Value
CEBS Accession Number: 002-02555-0002-0000-1
Chemical Name: N-Methylolacrylamide
CASRN: 924-42-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 193375_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 10/05/1987    Harvest Time: 20.2 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 2 0.010 0.5 0 0.000 0.0 2 0.010 0.5 0 0.000 0.0
Test Chemical: N-Methylolacrylamide 
250         
 200 16 0.080 7.0 5 0.025 2.5 11 0.055 5.0 0 0.000 0.0 
375         
 200 48 0.240 18.5 14 0.070 7.0 34 0.170 13.0 0 0.000 0.0 
500         
 50 57 1.140 52.0 16 0.320 26.0 41 0.820 34.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 67 0.335 24.0 38 0.190 15.5 29 0.145 13.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 15 0.600 40.0 7 0.280 20.0 8 0.320 28.0 0 0.000 0.0
Trend: 9.468 6.507 7.453  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/05/1987    Harvest Time: 20.2 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 3 0.015 0.5 0 0.000 0.0 3 0.015 0.5 0 0.000 0.0
Test Chemical: N-Methylolacrylamide 
2500         
 200 95 0.475 11.5 31 0.155 7.0 14 0.070 5.5 50 0.250 2.5 
3750         
 25 95 3.800 56.0 8 0.320 12.0 7 0.280 20.0 80 3.200 32.0 
5000         
 25 149 5.960 92.0 17 0.680 32.0 22 0.880 44.0 110 4.400 44.0
Positive Control: Cyclophosphamide 
6.25      
 200 34 0.170 14.0 16 0.080 8.0 18 0.090 7.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 42 1.680 72.0 14 0.560 36.0 18 0.720 56.0 10 0.400 4.0
Trend: 13.073 6.588 8.188  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 10/28/1987    Harvest Time: 20.3 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: N-Methylolacrylamide 
375         
 100 42 0.420 26.0 6 0.060 5.0 36 0.360 22.0 0 0.000 0.0 
437.5       
 50 53 1.060 64.0 14 0.280 24.0 39 0.780 46.0 0 0.000 0.0 
500         
 50 79 1.580 66.0 13 0.260 20.0 66 1.320 56.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 100 20 0.200 19.0 12 0.120 11.0 8 0.080 8.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 29 1.160 40.0 13 0.520 28.0 16 0.640 24.0 0 0.000 0.0
Trend: 9.802 5.253 8.448  
Probability: 0.000 0.000 0.000