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Study Information
Study Attribute Value
CEBS Accession Number: 002-02501-0001-0000-1
Chemical Name: N,N'-Di-sec-butyl-p-phenyldiamine
CASRN: 101-96-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 189593_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/06/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 520 0.496 10.40 26.5 0.000
Test Chemical N,N'-Di-sec-butyl-p-phenyldiamine 
 0.16      
 50 1049 530 0.505 10.60 26.5 1.923 
 0.5       
 50 1050 562 0.535 11.24 26.5 7.974 
1.6       
 50 1050 563 0.536 11.26 26.5 8.166 
5         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 636 0.606 12.72 26.5 22.191
Mitomycin-C 
 0.005     
 10 210 278 1.324 27.80 26.5 167.053
Trend: 1.522        
Probability: 0.064        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/06/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 429 0.411 8.58 26.0 0.000
Test Chemical N,N'-Di-sec-butyl-p-phenyldiamine 
 0.5       
 50 1050 466 0.444 9.32 26.0 7.901 
1.6       
 50 1049 434 0.414 8.68 26.0 0.587 
5         
 50 1050 479 0.456 9.58 26.0 10.911 
16         
 50 1051 509 0.484 10.18 26.0 17.745 
50         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.15      
 50 1049 746 0.711 14.92 26.0 72.898
Cyclophosphamide 
 0.6       
 10 210 243 1.157 24.30 26.0 181.329
Trend: 2.436        
Probability: 0.007