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Study Information
Study Attribute Value
CEBS Accession Number: 002-02500-0002-0000-1
Chemical Name: N,N'-Di-2-napthyl-p-phenylenediamine
CASRN: 93-46-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 999918_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 01/09/1986    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 1.0 1 0.005 1.0 0 0.000 0.0
Test Chemical: N,N'-Di-2-napthyl-p-phenylenediamine 
500         
 200 3 0.015 2.0 1 0.005 1.0 2 0.010 1.0 0 0.000 0.0 
1000         
 200 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0 
1600         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.063     
 200 22 0.110 9.0 8 0.040 4.0 14 0.070 6.0 0 0.000 0.0
Mitomycin-C 
 0.125     
 50 11 0.220 22.0 4 0.080 8.0 7 0.140 14.0 0 0.000 0.0
Trend: -1.244 -1.839 -1.042  
Probability: 0.893 0.967 0.851  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/09/1986    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0
Test Chemical: N,N'-Di-2-napthyl-p-phenylenediamine 
160         
 200 2 0.010 1.0 1 0.005 1.0 1 0.005 1.0 0 0.000 0.0 
300         
 200 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0 
500         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 
1000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 200 45 0.225 17.0 16 0.080 7.0 19 0.095 9.0 10 0.050 1.0
Cyclophosphamide 
7.5       
 50 22 0.440 28.0 5 0.100 8.0 17 0.340 26.0 0 0.000 0.0
Trend: 0.822 0.854 0.000  
Probability: 0.205 0.196 0.500