Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02476-0004-0000-5 |
Chemical Name: | Michler's ketone |
CASRN: | 90-94-8 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 913588_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Positive |
Induced Rat Liver S9 | 2_S9 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | |
Test Chemical: | Michler's ketone | 14 | 200 | 5 | 0.025 | 2.5 | 2 | 0.010 | 1.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
30 | 200 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
65 | 200 | 5 | 0.025 | 2.5 | 2 | 0.010 | 1.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.4 | 25 | 58 | 2.320 | 84.0 | 29 | 1.160 | 68.0 | 19 | 0.760 | 52.0 | 10 | 0.400 | 4.0 |
Trend: | 0.904 | 0.204 | 0.949 | ||||||||||||
Probability: | 0.183 | 0.419 | 0.171 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | |
Test Chemical: | Michler's ketone | 65 | 200 | 24 | 0.120 | 8.5 | 21 | 0.105 | 7.5 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
140 | 200 | 37 | 0.185 | 14.0 | 25 | 0.125 | 9.0 | 12 | 0.060 | 5.5 | 0 | 0.000 | 0.0 | ||
300 | 200 | 35 | 0.175 | 15.0 | 29 | 0.145 | 13.0 | 5 | 0.025 | 2.5 | 1 | 0.005 | 0.5 | ||
Positive Control: | Cyclophosphamide | 20 | 25 | 22 | 0.880 | 64.0 | 15 | 0.600 | 44.0 | 7 | 0.280 | 24.0 | 0 | 0.000 | 0.0 |
Trend: | 5.094 | 4.682 | 2.029 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.021 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 3 | 0.015 | 0.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 0.5 | 0 | 0.000 | 0.0 |
Negative (Not Specified) | 0 | 200 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Michler's ketone | 65 | 50 | 20 | 0.400 | 30.0 | 16 | 0.320 | 26.0 | 4 | 0.080 | 8.0 | 0 | 0.000 | 0.0 |
140 | 50 | 29 | 0.580 | 38.0 | 25 | 0.500 | 34.0 | 4 | 0.080 | 8.0 | 0 | 0.000 | 0.0 | ||
300 | 50 | 25 | 0.500 | 38.0 | 25 | 0.500 | 38.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 20 | 25 | 17 | 0.680 | 48.0 | 11 | 0.440 | 36.0 | 6 | 0.240 | 16.0 | 0 | 0.000 | 0.0 |
Trend: | 8.383 | 8.492 | 1.289 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.099 |