COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02476-0003-0000-4
Chemical Name: Michler's ketone
CASRN: 90-94-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 913588_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/17/1990    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 372 0.356 7.44 26.0 0.000
Dimethyl Sulfoxide 
0         
 50 1050 385 0.367 7.70 31.0 3.002
Test Chemical Michler's ketone 
3         
 50 2044 838 0.410 16.76 31.0 15.169 
10         
 50 2053 908 0.442 18.16 31.0 24.243 
30         
 50 2033 902 0.444 18.04 31.0 24.636 
100         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1045 579 0.554 11.58 26.0 55.645
Mitomycin-C 
 0.004     
 10 211 237 1.123 23.70 26.0 215.529
Trend: 3.557        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/17/1990    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 389 0.372 7.78 26.0 0.000
Dimethyl Sulfoxide 
0         
 50 1049 384 0.366 7.68 31.0 -1.662
Test Chemical Michler's ketone 
30         
 25 524 519 0.990 20.76 26.0 166.074 
100         
 25 996 1014 1.018 40.56 31.0 173.492 
300         
 25 993 1255 1.264 50.20 31.0 239.517
Positive Control Cyclophosphamide 
 0.125     
 50 1047 545 0.521 10.90 26.0 39.835
Cyclophosphamide 
 0.5       
 10 209 239 1.144 23.90 26.0 207.198
Trend: 20.261        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 11/08/1990    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 438 0.417 8.76 31.0 17.203
Dimethyl Sulfoxide 
0         
 50 1048 373 0.356 7.46 26.0 0.000
Test Chemical Michler's ketone 
30         
 25 524 519 0.990 20.76 31.0 178.284 
100         
 25 1026 1341 1.307 53.64 31.0 267.226 
300         
 25 1006 1288 1.280 51.52 31.0 259.725
Positive Control Cyclophosphamide 
 0.125     
 50 1050 528 0.503 10.56 26.0 41.285
Cyclophosphamide 
 0.5       
 10 211 211 1.000 21.10 26.0 180.965
Trend: 22.037        
Probability: 0.000