Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02476-0001-0000-2 |
Chemical Name: | Michler's ketone |
CASRN: | 90-94-8 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 242025_SCE |
Study Result: | Not a Valid Test |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Test Failure |
No Activation | 2 | Test Failure |
Induced Rat Liver S9 | 1_S9 | Negative |
Induced Rat Liver S9 | 2_S9 | Test Failure |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1031 | 385 | 0.373 | 7.70 | 26.5 | 0.000 |
Negative (Not Specified) | 0 | 50 | 1038 | 408 | 0.393 | 8.16 | 26.5 | 5.259 | |
Test Chemical | Michler's ketone | 0.16 | 50 | 1040 | 403 | 0.388 | 8.06 | 26.5 | 3.769 |
0.5 | 3 | 111 | 40 | 0.360 | 13.33 | 26.5 | -3.498 | ||
1.6 | 3 | 115 | 53 | 0.461 | 17.67 | 26.5 | 23.417 | ||
5 | 0 | 0 | 0 | 0.000 | 0.00 | 26.5 | N/A | ||
16 | 0 | 0 | 0 | 0.000 | 0.00 | 26.5 | N/A | ||
50 | 0 | 0 | 0 | 0.000 | 0.00 | 30.5 | N/A | ||
500 | 0 | 0 | 0 | 0.000 | 0.00 | 42.5 | N/A | ||
Positive Control | Mitomycin-C | 0.003 | 50 | 1048 | 1037 | 0.990 | 20.74 | 26.5 | 164.981 |
Mitomycin-C | 0.005 | 50 | 1046 | 1404 | 1.342 | 28.08 | 26.5 | 259.446 | |
Trend: | 1.084 | ||||||||
Probability: | 0.139 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1051 | 441 | 0.420 | 8.82 | 28.0 | 0.000 |
Negative (Not Specified) | 0 | 50 | 1041 | 444 | 0.427 | 8.88 | 28.0 | 1.647 | |
Test Chemical | Michler's ketone | 0.1 | 50 | 1046 | 418 | 0.400 | 8.36 | 34.0 | -4.762 |
0.5 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
1 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
5 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
10 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
25 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
100 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Mitomycin-C | 0.005 | 50 | 1046 | 1589 | 1.519 | 31.78 | 28.0 | 262.040 |
Trend: | -0.715 | ||||||||
Probability: | 0.763 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1038 | 452 | 0.435 | 9.04 | 26.5 | 12.528 |
Dimethyl Sulfoxide | 0 | 50 | 1044 | 404 | 0.387 | 8.08 | 26.5 | 0.000 | |
Test Chemical | Michler's ketone | 0.5 | 50 | 1047 | 362 | 0.346 | 7.24 | 26.5 | -10.653 |
1.6 | 50 | 1025 | 378 | 0.369 | 7.56 | 26.5 | -4.701 | ||
5 | 50 | 1036 | 390 | 0.376 | 7.80 | 26.5 | -2.720 | ||
16 | 50 | 1029 | 400 | 0.389 | 8.00 | 26.5 | 0.453 | ||
50 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 2 | 50 | 1049 | 1501 | 1.431 | 30.02 | 26.5 | 269.764 |
Trend: | 0.568 | ||||||||
Probability: | 0.285 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1046 | 447 | 0.427 | 8.94 | 32.0 | 1.822 |
Dimethyl Sulfoxide | 0 | 50 | 1046 | 439 | 0.420 | 8.78 | 32.0 | 0.000 | |
Test Chemical | Michler's ketone | 25 | 0 | 0 | 0 | 0.000 | 0.00 | 32.0 | N/A |
50 | 0 | 0 | 0 | 0.000 | 0.00 | 32.0 | N/A | ||
100 | 0 | 0 | 0 | 0.000 | 0.00 | 32.0 | N/A | ||
250 | 0 | 0 | 0 | 0.000 | 0.00 | 32.0 | N/A | ||
500 | 0 | 0 | 0 | 0.000 | 0.00 | 32.0 | N/A | ||
1000 | 0 | 0 | 0 | 0.000 | 0.00 | 32.0 | N/A | ||
Positive Control | Cyclophosphamide | 2 | 50 | 1050 | 1629 | 1.551 | 32.58 | 32.0 | 269.657 |
Trend: | 0.000 | ||||||||
Probability: | 0.000 |