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Study Information
Study Attribute Value
CEBS Accession Number: 002-02476-0001-0000-2
Chemical Name: Michler's ketone
CASRN: 90-94-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 242025_SCE
Study Result: Not a Valid Test

Study Result: Not a Valid Test
Activation Trial Trial Call
No Activation  Test Failure 
No Activation  Test Failure 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Test Failure 

Trial #: 1    Activation: No Activation    Date: 04/12/1983    Trial Call: Test Failure   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1031 385 0.373 7.70 26.5 0.000
Negative (Not Specified)
0         
50 1038 408 0.393 8.16 26.5 5.259
Test Chemical Michler's ketone
 0.16      
50 1040 403 0.388 8.06 26.5 3.769
 0.5       
3 111 40 0.360 13.33 26.5 -3.498
1.6       
3 115 53 0.461 17.67 26.5 23.417
5         
0 0 0 0.000 0.00 26.5 N/A
16         
0 0 0 0.000 0.00 26.5 N/A
50         
0 0 0 0.000 0.00 30.5 N/A
500         
0 0 0 0.000 0.00 42.5 N/A
Positive Control Mitomycin-C
 0.003     
50 1048 1037 0.990 20.74 26.5 164.981
Mitomycin-C
 0.005     
50 1046 1404 1.342 28.08 26.5 259.446
Trend: 1.084        
Probability: 0.139        

Trial #: 2    Activation: No Activation    Date: 05/07/1983    Trial Call: Test Failure   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1051 441 0.420 8.82 28.0 0.000
Negative (Not Specified)
0         
50 1041 444 0.427 8.88 28.0 1.647
Test Chemical Michler's ketone
 0.1       
50 1046 418 0.400 8.36 34.0 -4.762
 0.5       
0 0 0 0.000 0.00 0.0 N/A
1         
0 0 0 0.000 0.00 0.0 N/A
5         
0 0 0 0.000 0.00 0.0 N/A
10         
0 0 0 0.000 0.00 0.0 N/A
25         
0 0 0 0.000 0.00 0.0 N/A
100         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C
 0.005     
50 1046 1589 1.519 31.78 28.0 262.040
Trend: -0.715        
Probability: 0.763        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/12/1983    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1038 452 0.435 9.04 26.5 12.528
Dimethyl Sulfoxide
0         
50 1044 404 0.387 8.08 26.5 0.000
Test Chemical Michler's ketone
 0.5       
50 1047 362 0.346 7.24 26.5 -10.653
1.6       
50 1025 378 0.369 7.56 26.5 -4.701
5         
50 1036 390 0.376 7.80 26.5 -2.720
16         
50 1029 400 0.389 8.00 26.5 0.453
50         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide
2         
50 1049 1501 1.431 30.02 26.5 269.764
Trend: 0.568        
Probability: 0.285        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 05/07/1983    Trial Call: Test Failure   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1046 447 0.427 8.94 32.0 1.822
Dimethyl Sulfoxide
0         
50 1046 439 0.420 8.78 32.0 0.000
Test Chemical Michler's ketone
25         
0 0 0 0.000 0.00 32.0 N/A
50         
0 0 0 0.000 0.00 32.0 N/A
100         
0 0 0 0.000 0.00 32.0 N/A
250         
0 0 0 0.000 0.00 32.0 N/A
500         
0 0 0 0.000 0.00 32.0 N/A
1000         
0 0 0 0.000 0.00 32.0 N/A
Positive Control Cyclophosphamide
2         
50 1050 1629 1.551 32.58 32.0 269.657
Trend: 0.000        
Probability: 0.000