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Study Information
Study Attribute Value
CEBS Accession Number: 002-02191-0002-0000-7
Chemical Name: Fumaronitrile
CASRN: 764-42-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 546024_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 
No Activation  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 08/19/1986    Harvest Time: 21 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
200 7 0.035 3.0 0 0.000 0.0 7 0.035 3.0 0 0.000 0.0
Test Chemical: Fumaronitrile
 0.51      
200 13 0.065 6.0 4 0.020 2.0 9 0.045 4.0 0 0.000 0.0
 0.765     
200 11 0.055 5.0 3 0.015 1.5 8 0.040 3.5 0 0.000 0.0
1.02      
200 25 0.125 9.0 3 0.015 1.5 22 0.110 8.0 0 0.000 0.0
1.53      
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.2       
50 46 0.920 56.0 29 0.580 42.0 17 0.340 30.0 0 0.000 0.0
Mitomycin-C
5         
10 100 10.000 100.0 0 0.000 0.0 0 0.000 0.0 100 10.000 10.0
Trend: 2.236 1.161 2.078  
Probability: 0.013 0.123 0.019  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 07/24/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
200 10 0.050 5.0 2 0.010 1.0 8 0.040 4.0 0 0.000 0.0
Test Chemical: Fumaronitrile
 0.505     
200 8 0.040 3.5 4 0.020 2.0 4 0.020 1.5 0 0.000 0.0
1.52      
200 5 0.025 2.5 2 0.010 1.0 3 0.015 1.5 0 0.000 0.0
5.05      
200 12 0.060 6.0 0 0.000 0.0 12 0.060 6.0 0 0.000 0.0
10.1       
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide
50         
50 34 0.680 36.0 9 0.180 16.0 25 0.500 28.0 0 0.000 0.0
Trend: 0.385 -1.329 1.183  
Probability: 0.350 0.908 0.118  


Trial #:2   Activation: No Activation    Date: 07/24/1986    Harvest Time: 10 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
200 6 0.030 3.0 1 0.005 0.5 5 0.025 2.5 0 0.000 0.0
Test Chemical: Fumaronitrile
 0.101     
200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
 0.303     
200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
 0.505     
200 19 0.095 9.0 1 0.005 0.5 18 0.090 8.5 0 0.000 0.0
1.01      
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C
1         
200 103 0.515 34.0 43 0.215 17.0 50 0.250 21.0 10 0.050 1.0
Mitomycin-C
5         
50 70 1.400 68.0 21 0.420 30.0 39 0.780 58.0 10 0.200 1.0
Trend: 2.708 -0.098 2.823  
Probability: 0.003 0.539 0.002