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Study Information
Study Attribute Value
CEBS Accession Number: 002-02191-0001-0000-6
Chemical Name: Fumaronitrile
CASRN: 764-42-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 546024_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Weakly Positive 
No Activation  3  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 07/15/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 278 0.265 5.56 27.5 0.000
Negative (Not Specified) 
0         
 50 1043 356 0.341 7.12 27.0 28.671
Test Chemical Fumaronitrile 
 0.0499    
 50 1035 432 0.417 8.64 27.5 57.348 
 0.15      
 50 1039 473 0.455 9.46 27.5 71.618 
 0.499     
 50 1039 547 0.526 10.94 27.5 98.467 
1.5       
 0 0 0 0.000 0.00 31.5 N/A
Positive Control Mitomycin-C 
 0.002     
 50 1043 498 0.477 9.96 27.0 79.995
Mitomycin-C 
 0.01      
 10 208 114 0.548 11.40 27.0 106.613
Trend: 9.200        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/14/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1037 494 0.476 9.88 26.5 0.000
Test Chemical Fumaronitrile 
 0.1       
 50 1040 458 0.440 9.16 26.5 -7.555 
 0.499     
 50 1031 589 0.571 11.78 26.5 19.925 
 0.75      
 50 1032 569 0.551 11.38 26.5 15.740 
1         
 50 1026 629 0.613 12.58 26.5 28.693
Positive Control Mitomycin-C 
 0.0015    
 50 1032 2244 2.174 44.88 26.5 356.452
Mitomycin-C 
 0.01      
 10 210 1066 5.076 106.60 26.5 965.589
Trend: 5.576        
Probability: 0.000        

Trial #: 3    Activation: No Activation    Date: 09/18/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1028 459 0.446 9.18 26.5 0.000
Test Chemical Fumaronitrile 
 0.303     
 50 1039 565 0.544 11.30 26.5 21.790 
 0.404     
 50 1044 584 0.559 11.68 26.5 25.283 
 0.505     
 50 1038 693 0.668 13.86 26.5 49.526 
1.01      
 25 510 396 0.776 15.84 30.5 73.902
Positive Control Mitomycin-C 
 0.0E-4    
 50 1044 680 0.651 13.60 26.5 45.878
Mitomycin-C 
 0.01      
 10 209 961 4.598 96.10 26.5 929.811
Trend: 8.878        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/15/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 489 0.469 9.78 26.5 0.000
Test Chemical Fumaronitrile 
 0.499     
 50 1044 437 0.419 8.74 26.5 -10.805 
1.5       
 50 1043 459 0.440 9.18 26.5 -6.225 
4.99      
 50 1044 623 0.597 12.46 26.5 27.159 
15         
 0 0 0 0.000 0.00 30.5 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1034 706 0.683 14.12 25.5 45.493
Cyclophosphamide 
2.5       
 10 208 371 1.784 37.10 25.5 280.075
Trend: 4.279        
Probability: 0.000