Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02113-0008-0000-7
Chemical Name:	Endosulfan
CASRN:	115-29-7
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	309806
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Acetone	0	91	99	105	38	31
			85	91	75	29
			102	116	73	24
			94	94	90	32
Test Chemical	Endosulfan	3.125	70	79	81	38	34
			97	91	84	29	34
		6.25	83	90	98	40	38
			82	90	90	37	38
		12.5	70	60	87	42	40
			92	79	105	38	40
		25	30	4	2997	3367	2857*
			39	5	2711	2347	2857*
		50

Positive Control	Methyl Methane Sulfonate	15	49	32	169	115	103*
			75	38	205	92	103*
	Methyl Methane Sulfonate	250	81	86	530	219	234*
			67	76	498	248	234*

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Acetone	0	96	102	138	48	55
			94	104	136	48
			62	95	126	68
			74	99	123	56
Test Chemical	Endosulfan	9.3	88	90	134	51	54
			84	96	145	58	54
		14	71	66	153	72	63
			87	19	140	53	63
		18.6	88	58	240	91	92*
			91	52	257	94	92*
		23.3	60	14	623	347	299*
			66	18	500	251	299*
		28	39r	5	1544	1331
			38	4	1112	971
Positive Control	Methyl Methane Sulfonate	15	39	23	314	267	264*
			58	39	451	261	264*
	Methyl Methane Sulfonate	250	69	68	560	271	287*
			68	63	613	303	287*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination