Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02113-0002-0000-1 |
Chemical Name: | Endosulfan |
CASRN: | 115-29-7 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 447920_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Endosulfan | 5 | 200 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
10 | 177 | 1 | 0.006 | 0.6 | 0 | 0.000 | 0.0 | 1 | 0.006 | 0.6 | 0 | 0.000 | 0.0 | ||
16 | 200 | 4 | 0.020 | 1.5 | 0 | 0.000 | 0.0 | 4 | 0.020 | 1.5 | 0 | 0.000 | 0.0 | ||
30 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.0625 | 200 | 48 | 0.240 | 15.5 | 17 | 0.085 | 8.5 | 20 | 0.100 | 6.5 | 11 | 0.055 | 2.0 |
Mitomycin-C | 0.25 | 50 | 16 | 0.320 | 26.0 | 6 | 0.120 | 10.0 | 10 | 0.200 | 18.0 | 0 | 0.000 | 0.0 | |
Trend: | -0.561 | -0.715 | -0.314 | ||||||||||||
Probability: | 0.713 | 0.763 | 0.623 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
Test Chemical: | Endosulfan | 5 | 200 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
10 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
16 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 2.5 | 200 | 44 | 0.220 | 16.0 | 8 | 0.040 | 4.0 | 26 | 0.130 | 12.0 | 10 | 0.050 | 1.0 |
Cyclophosphamide | 7.5 | 50 | 18 | 0.360 | 30.0 | 3 | 0.060 | 6.0 | 15 | 0.300 | 28.0 | 0 | 0.000 | 0.0 | |
Trend: | -0.917 | 0.000 | -0.917 | ||||||||||||
Probability: | 0.821 | 0.000 | 0.821 |