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Study Information
Study Attribute Value
CEBS Accession Number: 002-02113-0001-0000-0
Chemical Name: Endosulfan
CASRN: 115-29-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 447920_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 12/09/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 394 0.376 7.88 26.0 0.000
Test Chemical Endosulfan 
 0.16      
 50 1050 382 0.364 7.64 26.0 -3.138 
 0.5       
 50 1051 449 0.427 8.98 26.0 13.743 
1.6       
 50 1050 435 0.414 8.70 26.0 10.301 
5         
 50 1050 459 0.437 9.18 26.0 16.387
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 509 0.486 10.18 26.0 29.311
Mitomycin-C 
 0.005     
 10 210 278 1.324 27.80 26.0 252.456
Trend: 2.796        
Probability: 0.003        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/09/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 404 0.385 8.08 26.0 0.000
Test Chemical Endosulfan 
 0.5       
 50 1049 439 0.418 8.78 26.0 8.663 
1.6       
 50 1050 412 0.392 8.24 26.0 1.883 
5         
 50 1050 439 0.418 8.78 26.0 8.560 
16         
 50 1048 433 0.413 8.66 26.0 7.280
Positive Control Cyclophosphamide 
 0.1       
 50 1049 531 0.506 10.62 26.0 31.436
Cyclophosphamide 
 0.6       
 10 210 228 1.086 22.80 26.0 181.909
Trend: 0.893        
Probability: 0.186