Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02113-0001-0000-0 |
Chemical Name: | Endosulfan |
CASRN: | 115-29-7 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 447920_SCE |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1049 | 394 | 0.376 | 7.88 | 26.0 | 0.000 |
Test Chemical | Endosulfan | 0.16 | 50 | 1050 | 382 | 0.364 | 7.64 | 26.0 | -3.138 |
0.5 | 50 | 1051 | 449 | 0.427 | 8.98 | 26.0 | 13.743 | ||
1.6 | 50 | 1050 | 435 | 0.414 | 8.70 | 26.0 | 10.301 | ||
5 | 50 | 1050 | 459 | 0.437 | 9.18 | 26.0 | 16.387 | ||
Positive Control | Mitomycin-C | 0.0E-4 | 50 | 1048 | 509 | 0.486 | 10.18 | 26.0 | 29.311 |
Mitomycin-C | 0.005 | 10 | 210 | 278 | 1.324 | 27.80 | 26.0 | 252.456 | |
Trend: | 2.796 | ||||||||
Probability: | 0.003 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1049 | 404 | 0.385 | 8.08 | 26.0 | 0.000 |
Test Chemical | Endosulfan | 0.5 | 50 | 1049 | 439 | 0.418 | 8.78 | 26.0 | 8.663 |
1.6 | 50 | 1050 | 412 | 0.392 | 8.24 | 26.0 | 1.883 | ||
5 | 50 | 1050 | 439 | 0.418 | 8.78 | 26.0 | 8.560 | ||
16 | 50 | 1048 | 433 | 0.413 | 8.66 | 26.0 | 7.280 | ||
Positive Control | Cyclophosphamide | 0.1 | 50 | 1049 | 531 | 0.506 | 10.62 | 26.0 | 31.436 |
Cyclophosphamide | 0.6 | 10 | 210 | 228 | 1.086 | 22.80 | 26.0 | 181.909 | |
Trend: | 0.893 | ||||||||
Probability: | 0.186 |