Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01962-0001-0000-1 |
Chemical Name: | Danthron |
CASRN: | 117-10-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | A87796_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 4 | 0.020 | 2.0 | 1 | 0.005 | 0.5 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 6 | 0.030 | 0.5 | 0 | 0.000 | 0.0 | 6 | 0.030 | 0.5 | 0 | 0.000 | 0.0 | |
Test Chemical: | Danthron | 17 | 50 | 55 | 1.100 | 64.0 | 24 | 0.480 | 42.0 | 31 | 0.620 | 38.0 | 0 | 0.000 | 0.0 |
37 | 50 | 66 | 1.320 | 60.0 | 22 | 0.440 | 36.0 | 44 | 0.880 | 40.0 | 0 | 0.000 | 0.0 | ||
80 | 50 | 90 | 1.800 | 64.0 | 25 | 0.500 | 36.0 | 55 | 1.100 | 48.0 | 10 | 0.200 | 2.0 | ||
Positive Control: | Mitomycin-C | 0.4 | 25 | 9 | 0.360 | 32.0 | 3 | 0.120 | 12.0 | 6 | 0.240 | 20.0 | 0 | 0.000 | 0.0 |
Trend: | 11.389 | 7.999 | 9.361 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Danthron | 17 | 200 | 8 | 0.040 | 3.5 | 2 | 0.010 | 1.0 | 6 | 0.030 | 2.5 | 0 | 0.000 | 0.0 |
37 | 200 | 11 | 0.055 | 5.0 | 9 | 0.045 | 4.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
80 | 200 | 14 | 0.070 | 5.0 | 4 | 0.020 | 2.0 | 10 | 0.050 | 3.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 20 | 25 | 14 | 0.560 | 40.0 | 7 | 0.280 | 24.0 | 7 | 0.280 | 20.0 | 0 | 0.000 | 0.0 |
Trend: | 2.891 | 2.174 | 1.874 | ||||||||||||
Probability: | 0.002 | 0.015 | 0.030 |