Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01931-0002-0000-8 |
Chemical Name: | Cyclophosphamide monohydrate |
CASRN: | 6055-19-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 661949_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Positive |
Induced Rat Liver S9 | 2_S9 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 6 | 0.030 | 2.0 | 1 | 0.005 | 0.5 | 5 | 0.025 | 1.5 | 0 | 0.000 | 0.0 |
Test Chemical: | Cyclophosphamide monohydrate | 1081 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
2325 | 200 | 14 | 0.070 | 2.0 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 10 | 0.050 | 1.0 | ||
5000 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.1 | 200 | 39 | 0.195 | 15.0 | 21 | 0.105 | 9.0 | 18 | 0.090 | 7.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.4 | 50 | 13 | 0.260 | 26.0 | 10 | 0.200 | 20.0 | 3 | 0.060 | 6.0 | 0 | 0.000 | 0.0 | |
Trend: | -0.520 | 0.448 | -0.953 | ||||||||||||
Probability: | 0.699 | 0.327 | 0.830 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Cyclophosphamide monohydrate | 15 | 50 | 58 | 1.160 | 54.0 | 25 | 0.500 | 42.0 | 13 | 0.260 | 22.0 | 20 | 0.400 | 2.0 |
32 | 50 | 96 | 1.920 | 66.0 | 49 | 0.980 | 58.0 | 26 | 0.520 | 36.0 | 21 | 0.420 | 3.0 | ||
70 | 50 | 116 | 2.320 | 88.0 | 64 | 1.280 | 68.0 | 52 | 1.040 | 64.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 5 | 200 | 42 | 0.210 | 19.0 | 22 | 0.110 | 10.5 | 20 | 0.100 | 9.5 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 15 | 50 | 25 | 0.500 | 38.0 | 16 | 0.320 | 28.0 | 9 | 0.180 | 16.0 | 0 | 0.000 | 0.0 | |
Trend: | 10.877 | 9.203 | 8.620 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Cyclophosphamide monohydrate | 32 | 25 | 53 | 2.120 | 76.0 | 22 | 0.880 | 56.0 | 11 | 0.440 | 32.0 | 20 | 0.800 | 2.0 |
70 | 25 | 62 | 2.480 | 96.0 | 27 | 1.080 | 68.0 | 24 | 0.960 | 76.0 | 11 | 0.440 | 2.0 | ||
150 | 25 | 101 | 4.040 | 88.0 | 42 | 1.680 | 60.0 | 18 | 0.720 | 44.0 | 41 | 1.640 | 5.0 | ||
Positive Control: | Cyclophosphamide | 5 | 200 | 47 | 0.235 | 18.0 | 21 | 0.105 | 10.0 | 26 | 0.130 | 9.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 15 | 50 | 29 | 0.580 | 40.0 | 20 | 0.400 | 26.0 | 9 | 0.180 | 18.0 | 0 | 0.000 | 0.0 | |
Trend: | 10.606 | 8.186 | 7.375 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |