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Study Information
Study Attribute Value
CEBS Accession Number: 002-01871-0002-0000-1
Chemical Name: Chloropicrin
CASRN: 76-06-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 405202_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Weakly Positive* 
Induced Rat Liver S9  1_S9  Weakly Positive* 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 09/28/1987    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: Chloropicrin
1.6       
200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
3         
200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
5         
200 17 0.085 7.5 6 0.030 3.0 10 0.050 5.0 1 0.005 1.0
Positive Control: Mitomycin-C
 0.0625    
200 35 0.175 16.0 19 0.095 9.5 16 0.080 7.5 0 0.000 0.0
Mitomycin-C
 0.25      
50 19 0.380 32.0 13 0.260 22.0 6 0.120 12.0 0 0.000 0.0
Trend: 3.965 2.482 3.302  
Probability: 0.000 0.007 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/03/1987    Harvest Time: 13 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Chloropicrin
5         
200 8 0.040 4.0 2 0.010 1.0 6 0.030 3.0 0 0.000 0.0
10         
200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
16         
200 63 0.315 21.0 7 0.035 3.5 27 0.135 12.5 29 0.145 11.0
Positive Control: Cyclophosphamide
2.5       
200 37 0.185 17.0 9 0.045 4.5 28 0.140 13.5 0 0.000 0.0
Cyclophosphamide
7.5       
50 19 0.380 34.0 4 0.080 8.0 15 0.300 28.0 0 0.000 0.0
Trend: 6.781 2.706 4.722  
Probability: 0.000 0.003 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 09/28/1987    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Chloropicrin
3         
200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
5         
200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
10         
200 10 0.050 4.0 6 0.030 2.5 4 0.020 1.5 0 0.000 0.0
16         
108 18 0.167 15.7 3 0.028 2.8 15 0.139 13.0 0 0.000 0.0
Positive Control: Cyclophosphamide
2.5       
200 42 0.210 18.0 9 0.045 4.0 33 0.165 15.0 0 0.000 0.0
Cyclophosphamide
7.5       
50 20 0.400 28.0 6 0.120 12.0 14 0.280 24.0 0 0.000 0.0
Trend: 6.027 3.314 5.008  
Probability: 0.000 0.000 0.000