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Study Information
Study Attribute Value
CEBS Accession Number: 002-01871-0001-0000-0
Chemical Name: Chloropicrin
CASRN: 76-06-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 405202_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Positive 
No Activation  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 06/24/1987    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1037 432 0.417 8.64 26.0 0.000
Test Chemical Chloropicrin
 0.16      
50 1049 446 0.425 8.92 26.0 2.060
 0.5       
50 1048 426 0.406 8.52 26.0 -2.424
1.6       
50 1044 546 0.523 10.92 26.0 25.541
5         
3 63 54 0.857 18.00 26.0 105.754
Positive Control Mitomycin-C
 0.0E-4    
50 1050 553 0.527 11.06 26.0 26.424
Mitomycin-C
 0.005     
10 210 306 1.457 30.60 26.0 249.782
Trend: 4.417        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 09/22/1987    Trial Call: Weakly Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1048 428 0.408 8.56 26.0 0.000
Test Chemical Chloropicrin
 0.5       
50 1047 355 0.339 7.10 26.0 -16.977
1.6       
50 1047 447 0.427 8.94 26.0 4.539
3         
50 1049 467 0.445 9.34 26.0 9.008
5         
50 1046 645 0.617 12.90 26.0 50.989
Positive Control Mitomycin-C
 0.0E-4    
50 1048 557 0.531 11.14 26.0 30.140
Mitomycin-C
 0.005     
10 210 231 1.100 23.10 26.0 169.346
Trend: 7.490        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/24/1987    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1050 431 0.410 8.62 26.0 0.000
Test Chemical Chloropicrin
 0.16      
50 1050 404 0.385 8.08 26.0 -6.265
 0.5       
50 1050 397 0.378 7.94 26.0 -7.889
1.6       
50 1050 390 0.371 7.80 26.0 -9.513
5         
50 1049 430 0.410 8.60 26.0 -0.137
Positive Control Cyclophosphamide
 0.1       
50 1049 520 0.496 10.40 26.0 20.765
Cyclophosphamide
 0.6       
10 210 232 1.105 23.20 26.0 169.142
Trend: -0.238        
Probability: 0.594