Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01871-0001-0000-0 |
Chemical Name: | Chloropicrin |
CASRN: | 76-06-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 405202_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
No Activation | 2 | Weakly Positive |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1037 | 432 | 0.417 | 8.64 | 26.0 | 0.000 |
Test Chemical | Chloropicrin | 0.16 | 50 | 1049 | 446 | 0.425 | 8.92 | 26.0 | 2.060 |
0.5 | 50 | 1048 | 426 | 0.406 | 8.52 | 26.0 | -2.424 | ||
1.6 | 50 | 1044 | 546 | 0.523 | 10.92 | 26.0 | 25.541 | ||
5 | 3 | 63 | 54 | 0.857 | 18.00 | 26.0 | 105.754 | ||
Positive Control | Mitomycin-C | 0.0E-4 | 50 | 1050 | 553 | 0.527 | 11.06 | 26.0 | 26.424 |
Mitomycin-C | 0.005 | 10 | 210 | 306 | 1.457 | 30.60 | 26.0 | 249.782 | |
Trend: | 4.417 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1048 | 428 | 0.408 | 8.56 | 26.0 | 0.000 |
Test Chemical | Chloropicrin | 0.5 | 50 | 1047 | 355 | 0.339 | 7.10 | 26.0 | -16.977 |
1.6 | 50 | 1047 | 447 | 0.427 | 8.94 | 26.0 | 4.539 | ||
3 | 50 | 1049 | 467 | 0.445 | 9.34 | 26.0 | 9.008 | ||
5 | 50 | 1046 | 645 | 0.617 | 12.90 | 26.0 | 50.989 | ||
Positive Control | Mitomycin-C | 0.0E-4 | 50 | 1048 | 557 | 0.531 | 11.14 | 26.0 | 30.140 |
Mitomycin-C | 0.005 | 10 | 210 | 231 | 1.100 | 23.10 | 26.0 | 169.346 | |
Trend: | 7.490 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1050 | 431 | 0.410 | 8.62 | 26.0 | 0.000 |
Test Chemical | Chloropicrin | 0.16 | 50 | 1050 | 404 | 0.385 | 8.08 | 26.0 | -6.265 |
0.5 | 50 | 1050 | 397 | 0.378 | 7.94 | 26.0 | -7.889 | ||
1.6 | 50 | 1050 | 390 | 0.371 | 7.80 | 26.0 | -9.513 | ||
5 | 50 | 1049 | 430 | 0.410 | 8.60 | 26.0 | -0.137 | ||
Positive Control | Cyclophosphamide | 0.1 | 50 | 1049 | 520 | 0.496 | 10.40 | 26.0 | 20.765 |
Cyclophosphamide | 0.6 | 10 | 210 | 232 | 1.105 | 23.20 | 26.0 | 169.142 | |
Trend: | -0.238 | ||||||||
Probability: | 0.594 |