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Study Information
Study Attribute Value
CEBS Accession Number: 002-01854-0001-0000-1
Chemical Name: Chlordane (analytical grade)
CASRN: 57-74-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 675840_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Test Failure 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Test Failure 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 09/27/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1033 457 0.442 9.14 25.5 0.000
Test Chemical Chlordane (analytical grade) 
5         
 50 1019 482 0.473 9.64 25.5 6.920
Positive Control Mitomycin-C 
 0.01      
 5 104 171 1.644 34.20 25.5 271.661
Trend: 0.000        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 10/12/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1028 446 0.434 8.92 25.8 0.000
Test Chemical Chlordane (analytical grade) 
7         
 50 1020 580 0.569 11.60 33.8 31.065 
10.1       
 50 1039 558 0.537 11.16 33.8 23.788 
13         
 50 1019 657 0.645 13.14 33.8 48.610 
14.9       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1037 661 0.637 13.22 25.8 46.920
Mitomycin-C 
 0.01      
 5 104 166 1.596 33.20 25.8 267.903
Trend: 5.575        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/27/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1032 469 0.454 9.38 25.5 0.000
Test Chemical Chlordane (analytical grade) 
16.7       
 50 1023 549 0.537 10.98 25.5 18.087
Positive Control Cyclophosphamide 
2         
 5 106 96 0.906 19.20 25.5 99.284
Trend: 0.000        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 10/12/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 481 0.467 9.62 25.8 0.000
Test Chemical Chlordane (analytical grade) 
20.1       
 50 1027 591 0.575 11.82 33.8 23.348 
24.9       
 50 1026 606 0.591 12.12 33.8 26.602 
30         
 50 1021 672 0.658 13.44 33.8 41.077 
35         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1040 550 0.529 11.00 25.8 13.356
Cyclophosphamide 
2         
 5 105 116 1.105 23.20 25.8 136.800
Trend: 5.545        
Probability: 0.000