Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01796-0002-0000-7 |
Chemical Name: | C.I. Disperse yellow 3 |
CASRN: | 2832-40-8 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 041446_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 4 | 0.020 | 2.0 | 3 | 0.015 | 2.0 | 1 | 0.005 | 1.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.005 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | C.I. Disperse yellow 3 | 150.9 | 200 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 |
502.5 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
1000 | 200 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
1500 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.05 | 200 | 37 | 0.185 | 14.0 | 20 | 0.100 | 8.0 | 17 | 0.085 | 8.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.08 | 25 | 19 | 0.760 | 48.0 | 7 | 0.280 | 28.0 | 12 | 0.480 | 36.0 | 0 | 0.000 | 0.0 | |
Trend: | -0.829 | 1.797 | -1.876 | ||||||||||||
Probability: | 0.796 | 0.036 | 0.970 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.005 | 1.0 | 1 | 0.005 | 1.0 |
Dimethyl Sulfoxide | 0 | 200 | 6 | 0.030 | 3.0 | 2 | 0.010 | 1.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | C.I. Disperse yellow 3 | 996 | 200 | 6 | 0.030 | 3.0 | 1 | 0.005 | 1.0 | 5 | 0.025 | 3.0 | 0 | 0.000 | 0.0 |
1200 | 200 | 5 | 0.025 | 3.0 | 1 | 0.005 | 1.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
1500 | 200 | 5 | 0.025 | 2.0 | 2 | 0.010 | 1.0 | 3 | 0.015 | 2.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 7.5 | 200 | 29 | 0.145 | 12.0 | 15 | 0.075 | 7.0 | 14 | 0.070 | 7.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 37.5 | 25 | 14 | 0.560 | 36.0 | 7 | 0.280 | 24.0 | 7 | 0.280 | 24.0 | 0 | 0.000 | 0.0 | |
Trend: | -0.594 | 0.000 | -0.205 | ||||||||||||
Probability: | 0.724 | 0.500 | 0.581 |