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Study Information
Study Attribute Value
CEBS Accession Number: 002-01796-0001-0000-6
Chemical Name: C.I. Disperse yellow 3
CASRN: 2832-40-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 041446_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/17/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1030 421 0.409 8.42 25.5 0.000
Test Chemical C.I. Disperse yellow 3 
1.5       
 50 1040 481 0.463 9.62 25.5 13.153 
5         
 50 1031 440 0.427 8.80 32.3 4.412 
15         
 50 1044 555 0.532 11.10 32.3 30.061 
50         
 0 0 0 0.000 0.00 32.3 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1039 564 0.543 11.28 25.5 32.806
Mitomycin-C 
 0.01      
 5 105 194 1.848 38.80 25.5 352.030
Trend: 3.504        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 05/09/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 521 226 0.434 9.04 25.5 0.000
Test Chemical C.I. Disperse yellow 3 
5         
 25 525 282 0.537 11.28 35.7 23.828 
10         
 25 524 257 0.490 10.28 35.7 13.066 
14.9       
 25 519 284 0.547 11.36 35.7 26.148 
24.9       
 0 0 0 0.000 0.00 35.7 N/A
Positive Control Mitomycin-C 
 0.001     
 25 523 288 0.551 11.52 25.5 26.946
Mitomycin-C 
 0.01      
 5 106 193 1.821 38.60 25.5 319.740
Trend: 1.992        
Probability: 0.023        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/17/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 464 0.450 9.28 25.5 0.000
Test Chemical C.I. Disperse yellow 3 
150         
 50 1034 447 0.432 8.94 25.5 -3.943 
500         
 50 1026 482 0.470 9.64 25.5 4.386 
1500         
 50 1035 521 0.503 10.42 25.5 11.851
Positive Control Cyclophosphamide 
 0.4       
 50 1035 603 0.583 12.06 25.5 29.455
Cyclophosphamide 
2         
 5 107 247 2.308 49.40 25.5 412.925
Trend: 2.081        
Probability: 0.019