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Study Information
Study Attribute Value
CEBS Accession Number: 002-01795-0001-0000-5
Chemical Name: C.I. Disperse red 60
CASRN: 17418-58-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 448988_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/04/1987    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1028 433 0.421 8.66 26.0 0.000
Test Chemical C.I. Disperse red 60
5         
50 1038 441 0.425 8.82 26.0 0.866
16         
50 1034 389 0.376 7.78 26.0 -10.683
50         
50 1027 393 0.383 7.86 26.0 -9.149
100         
50 1033 487 0.471 9.74 26.0 11.927
Positive Control Mitomycin-C
 0.0E-4    
50 1030 554 0.538 11.08 26.0 27.696
Mitomycin-C
 0.005     
10 208 207 0.995 20.70 26.0 136.272
Trend: 0.643        
Probability: 0.260        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/04/1987    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1050 446 0.425 8.92 26.0 0.000
Test Chemical C.I. Disperse red 60
5         
50 1047 494 0.472 9.88 26.0 11.080
16         
50 1049 451 0.430 9.02 26.0 1.217
50         
50 1048 482 0.460 9.64 26.0 8.278
100         
50 1050 475 0.452 9.50 26.0 6.502
Positive Control Cyclophosphamide
 0.1       
50 1050 556 0.530 11.12 26.0 24.664
Cyclophosphamide
 0.6       
10 210 220 1.048 22.00 26.0 146.637
Trend: 0.654        
Probability: 0.256