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Study Information
Study Attribute Value
CEBS Accession Number: 002-01712-0002-0000-5
Chemical Name: Benzyl acetate
CASRN: 140-11-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 453123_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  2_S9  Negative 
No Activation  3  Negative 

Trial #:1   Activation: No Activation    Date: 05/05/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Benzyl acetate 
160         
 100 4 0.040 3.0 0 0.000 0.0 4 0.040 3.0 0 0.000 0.0 
500         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
1600         
 100 13 0.130 12.0 0 0.000 0.0 13 0.130 12.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 100 37 0.370 30.0 12 0.120 12.0 25 0.250 21.0 0 0.000 0.0
Trend: 2.025 -1.342 2.361  
Probability: 0.021 0.910 0.009  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/05/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 10 0.100 7.0 1 0.010 1.0 9 0.090 6.0 0 0.000 0.0
Test Chemical: Benzyl acetate 
500         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0 
1600         
 100 12 0.120 11.0 5 0.050 4.0 7 0.070 7.0 0 0.000 0.0 
5000         
 100 9 0.090 7.0 1 0.010 1.0 8 0.080 6.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 21 0.210 20.0 10 0.100 10.0 11 0.110 10.0 0 0.000 0.0
Trend: 0.515 0.519 0.290  
Probability: 0.303 0.302 0.386  


Trial #:2   Activation: No Activation    Date: 12/08/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 3.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Benzyl acetate 
500         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0 
1000         
 100 5 0.050 5.0 2 0.020 2.0 3 0.030 3.0 0 0.000 0.0 
1500         
 100 11 0.110 9.0 2 0.020 2.0 9 0.090 7.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 17 0.340 30.0 8 0.160 16.0 9 0.180 16.0 0 0.000 0.0
Trend: 1.688 0.761 1.112  
Probability: 0.046 0.223 0.133  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 09/22/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Benzyl acetate 
3000         
 100 10 0.100 9.0 3 0.030 3.0 7 0.070 6.0 0 0.000 0.0 
4000         
 100 9 0.090 8.0 3 0.030 2.0 6 0.060 6.0 0 0.000 0.0 
5000         
 100 9 0.090 9.0 4 0.040 4.0 5 0.050 5.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 18 0.180 14.0 8 0.080 8.0 10 0.100 8.0 0 0.000 0.0
Trend: 1.183 1.627 0.315  
Probability: 0.118 0.052 0.376  


Trial #:3   Activation: No Activation    Date: 09/16/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 8 0.080 8.0 2 0.020 2.0 6 0.060 6.0 0 0.000 0.0
Test Chemical: Benzyl acetate 
800         
 100 13 0.130 12.0 1 0.010 1.0 12 0.120 12.0 0 0.000 0.0 
1200         
 100 12 0.120 8.0 0 0.000 0.0 12 0.120 8.0 0 0.000 0.0 
1600         
 100 6 0.060 6.0 0 0.000 0.0 6 0.060 6.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 26 0.520 40.0 5 0.100 10.0 21 0.420 32.0 0 0.000 0.0
Trend: -0.800 -1.845 -0.324  
Probability: 0.788 0.967 0.627