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Study Information
Study Attribute Value
CEBS Accession Number: 002-01712-0001-0000-4
Chemical Name: Benzyl acetate
CASRN: 140-11-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 453123_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 05/05/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 518 0.494 10.36 26.0 0.000
Test Chemical Benzyl acetate 
50         
 50 1048 449 0.428 8.98 26.0 -13.238 
160         
 50 1048 473 0.451 9.46 26.0 -8.600 
500         
 50 1050 487 0.464 9.74 26.0 -6.074
Positive Control Mitomycin-C 
 0.005     
 50 1050 1174 1.118 23.48 26.0 126.425
Trend: -0.718        
Probability: 0.764        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/05/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 461 0.439 9.22 26.0 0.000
Test Chemical Benzyl acetate 
500         
 50 1050 484 0.461 9.68 26.0 5.089 
1600         
 50 1047 493 0.471 9.86 26.0 7.350 
5000         
 50 1048 515 0.491 10.30 28.0 12.033
Positive Control Cyclophosphamide 
1         
 50 1049 862 0.822 17.24 26.0 87.341
Trend: 1.786        
Probability: 0.037