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Study Information
Study Attribute Value
CEBS Accession Number: 002-01703-0002-0000-5
Chemical Name: Benzofuran
CASRN: 271-89-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 622347_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 05/24/1983    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Benzofuran
224         
100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
248.8       
100 6 0.060 4.0 1 0.010 1.0 3 0.030 2.0 2 0.020 2.0
276.6       
100 4 0.040 4.0 0 0.000 0.0 2 0.020 2.0 2 0.020 2.0
299.7       
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.0625    
50 32 0.640 44.0 20 0.400 28.0 12 0.240 18.0 0 0.000 0.0
Trend: 1.052 -0.787 0.738  
Probability: 0.146 0.784 0.230  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/24/1983    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 4 0.040 3.0 2 0.020 2.0 2 0.020 1.0 0 0.000 0.0
Test Chemical: Benzofuran
149.7       
100 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 1 0.010 1.0
200.8       
100 3 0.030 2.0 0 0.000 0.0 3 0.030 2.0 0 0.000 0.0
249.5       
100 9 0.090 2.0 2 0.020 2.0 7 0.070 1.0 0 0.000 0.0
275         
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide
50         
50 30 0.600 36.0 18 0.360 24.0 11 0.220 16.0 1 0.020 2.0
Trend: -0.265 0.027 0.541  
Probability: 0.605 0.489 0.294