Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01678-0002-0000-6 |
Chemical Name: | Azodicarbonamide |
CASRN: | 123-77-3 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 998177_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Positive |
No Activation | 2 | Questionable |
Induced Rat Liver S9 | 2_S9 | Weakly Positive* |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Azodicarbonamide | 402 | 100 | 3 | 0.030 | 3.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
498 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
600 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | ||
720 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.025 | 100 | 10 | 0.100 | 7.0 | 4 | 0.040 | 3.0 | 6 | 0.060 | 5.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.0625 | 25 | 12 | 0.480 | 32.0 | 5 | 0.200 | 20.0 | 7 | 0.280 | 16.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.273 | -0.262 | -0.007 | ||||||||||||
Probability: | 0.393 | 0.603 | 0.503 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Azodicarbonamide | 900 | 200 | 17 | 0.085 | 6.5 | 8 | 0.040 | 3.0 | 9 | 0.045 | 3.5 | 0 | 0.000 | 0.0 |
1020 | 200 | 9 | 0.045 | 4.5 | 3 | 0.015 | 1.5 | 6 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
1104 | 200 | 13 | 0.065 | 6.0 | 7 | 0.035 | 3.5 | 6 | 0.030 | 2.5 | 0 | 0.000 | 0.0 | ||
1290 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 2.5 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 12.5 | 25 | 14 | 0.560 | 40.0 | 6 | 0.240 | 24.0 | 8 | 0.320 | 20.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.508 | 1.296 | 0.825 | ||||||||||||
Probability: | 0.066 | 0.097 | 0.205 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 2.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 2.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Azodicarbonamide | 402 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
498 | 100 | 12 | 0.120 | 9.0 | 5 | 0.050 | 4.0 | 7 | 0.070 | 5.0 | 0 | 0.000 | 0.0 | ||
702 | 100 | 3 | 0.030 | 2.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
798 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.025 | 100 | 11 | 0.110 | 9.0 | 4 | 0.040 | 4.0 | 7 | 0.070 | 6.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.0625 | 27 | 7 | 0.259 | 19.0 | 2 | 0.074 | 7.0 | 5 | 0.185 | 19.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.499 | 1.345 | -0.059 | ||||||||||||
Probability: | 0.309 | 0.089 | 0.524 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Azodicarbonamide | 900 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
1002 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
1104 | 200 | 66 | 0.330 | 24.0 | 26 | 0.130 | 11.5 | 40 | 0.200 | 16.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 2.5 | 100 | 7 | 0.070 | 7.0 | 2 | 0.020 | 2.0 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 12.5 | 25 | 7 | 0.280 | 24.0 | 3 | 0.120 | 12.0 | 3 | 0.120 | 12.0 | 1 | 0.040 | 1.0 | |
Trend: | 6.328 | 4.577 | 4.983 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |