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Study Information
Study Attribute Value
CEBS Accession Number: 002-01678-0001-0000-5
Chemical Name: Azodicarbonamide
CASRN: 123-77-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 998177_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 02/27/1984    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1020 363 0.356 7.26 26.0 0.000
Test Chemical Azodicarbonamide
20         
50 1027 440 0.428 8.80 26.0 20.386
60         
50 1038 422 0.407 8.44 26.0 14.237
200         
25 515 210 0.408 8.40 34.0 14.579
600         
0 0 0 0.000 0.00 0.0 N/A
900         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C
 0.0015    
50 1039 582 0.560 11.64 26.0 57.399
Mitomycin-C
 0.01      
5 104 216 2.077 43.20 26.0 483.598
Trend: 1.466        
Probability: 0.071        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/27/1984    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1036 579 0.559 11.58 26.0 0.000
Test Chemical Azodicarbonamide
60         
50 1044 612 0.586 12.24 26.0 4.890
200         
50 1042 572 0.549 11.44 26.0 -1.778
600         
0 0 0 0.000 0.00 26.0 N/A
900         
50 1035 648 0.626 12.96 34.0 12.025
1200         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide
 0.4       
50 1033 733 0.710 14.66 26.0 26.965
Cyclophosphamide
2         
5 104 186 1.788 37.20 26.0 220.008
Trend: 1.663        
Probability: 0.048