Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01678-0001-0000-5 |
Chemical Name: | Azodicarbonamide |
CASRN: | 123-77-3 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 998177_SCE |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1020 | 363 | 0.356 | 7.26 | 26.0 | 0.000 |
Test Chemical | Azodicarbonamide | 20 | 50 | 1027 | 440 | 0.428 | 8.80 | 26.0 | 20.386 |
60 | 50 | 1038 | 422 | 0.407 | 8.44 | 26.0 | 14.237 | ||
200 | 25 | 515 | 210 | 0.408 | 8.40 | 34.0 | 14.579 | ||
600 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
900 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Mitomycin-C | 0.0015 | 50 | 1039 | 582 | 0.560 | 11.64 | 26.0 | 57.399 |
Mitomycin-C | 0.01 | 5 | 104 | 216 | 2.077 | 43.20 | 26.0 | 483.598 | |
Trend: | 1.466 | ||||||||
Probability: | 0.071 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1036 | 579 | 0.559 | 11.58 | 26.0 | 0.000 |
Test Chemical | Azodicarbonamide | 60 | 50 | 1044 | 612 | 0.586 | 12.24 | 26.0 | 4.890 |
200 | 50 | 1042 | 572 | 0.549 | 11.44 | 26.0 | -1.778 | ||
600 | 0 | 0 | 0 | 0.000 | 0.00 | 26.0 | N/A | ||
900 | 50 | 1035 | 648 | 0.626 | 12.96 | 34.0 | 12.025 | ||
1200 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.4 | 50 | 1033 | 733 | 0.710 | 14.66 | 26.0 | 26.965 |
Cyclophosphamide | 2 | 5 | 104 | 186 | 1.788 | 37.20 | 26.0 | 220.008 | |
Trend: | 1.663 | ||||||||
Probability: | 0.048 |