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Study Information
Study Attribute Value
CEBS Accession Number: 002-01653-0001-0000-8
Chemical Name: Anilazine
CASRN: 101-05-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 443411_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Test Failure 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 09/08/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1040 345 0.332 6.90 26.0 0.000
Negative (Not Specified) 
0         
 50 1042 348 0.334 6.96 26.0 0.676
Test Chemical Anilazine 
 0.05      
 50 1040 357 0.343 7.14 26.0 3.478 
 0.16      
 50 1044 364 0.349 7.28 26.0 5.103 
 0.5       
 50 1040 362 0.348 7.24 26.0 4.928 
1.6       
 50 1041 410 0.394 8.20 26.0 18.726 
5         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.003     
 50 1035 1090 1.053 21.80 26.0 217.468
Mitomycin-C 
 0.005     
 50 1046 1576 1.507 31.52 26.0 354.191
Trend: 2.217        
Probability: 0.013        

Trial #: 2    Activation: No Activation    Date: 11/20/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1036 436 0.421 8.72 27.0 1.574
Dimethyl Sulfoxide 
0         
 50 1033 428 0.414 8.56 27.0 0.000
Test Chemical Anilazine 
1         
 50 1039 433 0.417 8.66 27.0 0.584 
2         
 50 1034 523 0.506 10.46 31.0 22.078 
2         
 50 1040 539 0.518 10.78 27.0 25.087 
5         
 50 1047 624 0.596 12.48 31.0 43.845 
10         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1047 1945 1.858 38.90 27.0 348.363
Trend: 6.833        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/08/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1044 381 0.365 7.62 26.0 3.516
Dimethyl Sulfoxide 
0         
 50 1041 367 0.353 7.34 26.0 0.000
Test Chemical Anilazine 
 0.5       
 50 1041 454 0.436 9.08 26.0 23.706 
1.6       
 0 0 0 0.000 0.00 26.0 N/A 
5         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
2         
 50 1048 1845 1.760 36.90 26.0 399.367
Trend: 3.036        
Probability: 0.001        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 11/20/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1040 418 0.402 8.36 27.0 0.000
Negative (Not Specified) 
0         
 50 1035 459 0.443 9.18 26.0 10.339
Test Chemical Anilazine 
1.5       
 50 1035 472 0.456 9.44 27.0 13.464 
2         
 50 1035 481 0.465 9.62 27.0 15.628 
2.5       
 50 1042 476 0.457 9.52 27.0 13.657 
5         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
2         
 50 1041 3041 2.921 60.82 26.0 626.813
Trend: 2.059        
Probability: 0.020