COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01583-0002-0000-1
Chemical Name: Acetaldehyde
CASRN: 75-07-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 368663_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  Positive 

Trial #:1   Activation: No Activation    Date: 02/16/1989    Harvest Time: 16.3 hour(s)   Trial Call: Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Negative (Not Specified)
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Acetaldehyde
109         
50 10 0.200 16.0 3 0.060 6.0 7 0.140 12.0 0 0.000 0.0
234         
50 44 0.880 44.0 15 0.300 22.0 19 0.380 26.0 10 0.200 2.0
503         
50 43 0.860 36.0 11 0.220 18.0 32 0.640 32.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.1       
200 67 0.335 25.0 49 0.245 19.5 18 0.090 7.5 0 0.000 0.0
Mitomycin-C
 0.4       
50 37 0.740 46.0 25 0.500 40.0 12 0.240 22.0 0 0.000 0.0
Trend: 8.574 5.909 7.687  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/16/1989    Harvest Time: 14.2 hour(s)   Trial Call: Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
200 3 0.015 1.0 0 0.000 0.0 3 0.015 1.0 0 0.000 0.0
Test Chemical: Acetaldehyde
503         
50 5 0.100 10.0 4 0.080 8.0 1 0.020 2.0 0 0.000 0.0
1081         
50 14 0.280 22.0 10 0.200 16.0 4 0.080 8.0 0 0.000 0.0
2325         
50 29 0.580 28.0 11 0.220 18.0 8 0.160 10.0 10 0.200 2.0
5000         
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide
5         
200 47 0.235 17.0 20 0.100 8.0 27 0.135 10.0 0 0.000 0.0
Cyclophosphamide
15         
50 32 0.640 34.0 20 0.400 24.0 12 0.240 18.0 0 0.000 0.0
Trend: 6.854 5.803 3.581  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 03/24/1989    Harvest Time: 16.3 hour(s)   Trial Call: Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Negative (Not Specified)
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Acetaldehyde
109         
50 10 0.200 16.0 5 0.100 8.0 5 0.100 10.0 0 0.000 0.0
234         
50 21 0.420 34.0 12 0.240 20.0 9 0.180 18.0 0 0.000 0.0
503         
50 75 1.500 46.0 34 0.680 40.0 31 0.620 30.0 10 0.200 2.0
Positive Control: Mitomycin-C
 0.1       
200 54 0.270 18.0 28 0.140 10.5 26 0.130 10.0 0 0.000 0.0
Mitomycin-C
 0.4       
50 21 0.420 32.0 13 0.260 24.0 8 0.160 12.0 0 0.000 0.0
Trend: 7.131 6.835 5.341  
Probability: 0.000 0.000 0.000