Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01583-0002-0000-1 |
Chemical Name: | Acetaldehyde |
CASRN: | 75-07-0 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 368663_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
No Activation | 2 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Negative (Not Specified) | 0 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Acetaldehyde | 109 | 50 | 10 | 0.200 | 16.0 | 3 | 0.060 | 6.0 | 7 | 0.140 | 12.0 | 0 | 0.000 | 0.0 |
234 | 50 | 44 | 0.880 | 44.0 | 15 | 0.300 | 22.0 | 19 | 0.380 | 26.0 | 10 | 0.200 | 2.0 | ||
503 | 50 | 43 | 0.860 | 36.0 | 11 | 0.220 | 18.0 | 32 | 0.640 | 32.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.1 | 200 | 67 | 0.335 | 25.0 | 49 | 0.245 | 19.5 | 18 | 0.090 | 7.5 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.4 | 50 | 37 | 0.740 | 46.0 | 25 | 0.500 | 40.0 | 12 | 0.240 | 22.0 | 0 | 0.000 | 0.0 | |
Trend: | 8.574 | 5.909 | 7.687 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 3 | 0.015 | 1.0 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Acetaldehyde | 503 | 50 | 5 | 0.100 | 10.0 | 4 | 0.080 | 8.0 | 1 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
1081 | 50 | 14 | 0.280 | 22.0 | 10 | 0.200 | 16.0 | 4 | 0.080 | 8.0 | 0 | 0.000 | 0.0 | ||
2325 | 50 | 29 | 0.580 | 28.0 | 11 | 0.220 | 18.0 | 8 | 0.160 | 10.0 | 10 | 0.200 | 2.0 | ||
5000 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 5 | 200 | 47 | 0.235 | 17.0 | 20 | 0.100 | 8.0 | 27 | 0.135 | 10.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 15 | 50 | 32 | 0.640 | 34.0 | 20 | 0.400 | 24.0 | 12 | 0.240 | 18.0 | 0 | 0.000 | 0.0 | |
Trend: | 6.854 | 5.803 | 3.581 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Negative (Not Specified) | 0 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Acetaldehyde | 109 | 50 | 10 | 0.200 | 16.0 | 5 | 0.100 | 8.0 | 5 | 0.100 | 10.0 | 0 | 0.000 | 0.0 |
234 | 50 | 21 | 0.420 | 34.0 | 12 | 0.240 | 20.0 | 9 | 0.180 | 18.0 | 0 | 0.000 | 0.0 | ||
503 | 50 | 75 | 1.500 | 46.0 | 34 | 0.680 | 40.0 | 31 | 0.620 | 30.0 | 10 | 0.200 | 2.0 | ||
Positive Control: | Mitomycin-C | 0.1 | 200 | 54 | 0.270 | 18.0 | 28 | 0.140 | 10.5 | 26 | 0.130 | 10.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.4 | 50 | 21 | 0.420 | 32.0 | 13 | 0.260 | 24.0 | 8 | 0.160 | 12.0 | 0 | 0.000 | 0.0 | |
Trend: | 7.131 | 6.835 | 5.341 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |