Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01583-0001-0000-0 |
Chemical Name: | Acetaldehyde |
CASRN: | 75-07-0 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 368663_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
No Activation | 2 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1040 | 404 | 0.388 | 8.08 | 26.0 | -2.183 |
Dimethyl Sulfoxide | 0 | 50 | 1045 | 415 | 0.397 | 8.30 | 26.0 | 0.000 | |
Test Chemical | Acetaldehyde | 0.5 | 50 | 1035 | 477 | 0.461 | 9.54 | 26.0 | 16.050 |
1.7 | 50 | 1034 | 497 | 0.481 | 9.94 | 26.0 | 21.033 | ||
5 | 50 | 1039 | 609 | 0.586 | 12.18 | 26.0 | 47.594 | ||
17 | 50 | 1044 | 1572 | 1.506 | 31.44 | 26.0 | 279.158 | ||
50 | 15 | 312 | 1540 | 4.936 | 102.67 | 31.0 | 1142.895 | ||
167 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
1667 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1048 | 650 | 0.620 | 13.00 | 26.0 | 56.178 |
Mitomycin-C | 0.005 | 10 | 209 | 273 | 1.306 | 27.30 | 26.0 | 228.916 | |
Trend: | 55.048 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1050 | 362 | 0.345 | 7.24 | 26.0 | -15.984 |
Dimethyl Sulfoxide | 0 | 50 | 1043 | 428 | 0.410 | 8.56 | 26.0 | 0.000 | |
Test Chemical | Acetaldehyde | 1.7 | 50 | 1051 | 492 | 0.468 | 9.84 | 26.0 | 14.078 |
5 | 50 | 1044 | 572 | 0.548 | 11.44 | 26.0 | 33.517 | ||
17 | 50 | 1046 | 1453 | 1.389 | 29.06 | 26.0 | 238.512 | ||
50 | 50 | 1046 | 3938 | 3.765 | 78.76 | 31.0 | 817.455 | ||
167 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1043 | 591 | 0.567 | 11.82 | 26.0 | 38.084 |
Mitomycin-C | 0.005 | 10 | 209 | 279 | 1.335 | 27.90 | 26.0 | 225.311 | |
Trend: | 67.956 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1048 | 408 | 0.389 | 8.16 | 26.0 | -0.979 |
Dimethyl Sulfoxide | 0 | 50 | 1053 | 414 | 0.393 | 8.28 | 26.0 | 0.000 | |
Test Chemical | Acetaldehyde | 17 | 50 | 1051 | 441 | 0.420 | 8.82 | 26.0 | 6.724 |
50 | 50 | 1047 | 599 | 0.572 | 11.98 | 26.0 | 45.515 | ||
167 | 50 | 1047 | 1370 | 1.309 | 27.40 | 26.0 | 232.814 | ||
500 | 50 | 1050 | 4044 | 3.851 | 80.88 | 31.0 | 879.602 | ||
1667 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.125 | 50 | 1042 | 658 | 0.631 | 13.16 | 26.0 | 60.615 |
Cyclophosphamide | 0.5 | 10 | 212 | 191 | 0.901 | 19.10 | 26.0 | 129.153 | |
Trend: | 69.924 | ||||||||
Probability: | 0.000 |