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Study Information
Study Attribute Value
CEBS Accession Number: 002-01583-0001-0000-0
Chemical Name: Acetaldehyde
CASRN: 75-07-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 368663_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Positive 
No Activation  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/31/1989    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1040 404 0.388 8.08 26.0 -2.183
Dimethyl Sulfoxide
0         
50 1045 415 0.397 8.30 26.0 0.000
Test Chemical Acetaldehyde
 0.5       
50 1035 477 0.461 9.54 26.0 16.050
1.7       
50 1034 497 0.481 9.94 26.0 21.033
5         
50 1039 609 0.586 12.18 26.0 47.594
17         
50 1044 1572 1.506 31.44 26.0 279.158
50         
15 312 1540 4.936 102.67 31.0 1142.895
167         
0 0 0 0.000 0.00 0.0 N/A
1667         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C
 0.001     
50 1048 650 0.620 13.00 26.0 56.178
Mitomycin-C
 0.005     
10 209 273 1.306 27.30 26.0 228.916
Trend: 55.048        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 03/13/1989    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1050 362 0.345 7.24 26.0 -15.984
Dimethyl Sulfoxide
0         
50 1043 428 0.410 8.56 26.0 0.000
Test Chemical Acetaldehyde
1.7       
50 1051 492 0.468 9.84 26.0 14.078
5         
50 1044 572 0.548 11.44 26.0 33.517
17         
50 1046 1453 1.389 29.06 26.0 238.512
50         
50 1046 3938 3.765 78.76 31.0 817.455
167         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C
 0.001     
50 1043 591 0.567 11.82 26.0 38.084
Mitomycin-C
 0.005     
10 209 279 1.335 27.90 26.0 225.311
Trend: 67.956        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/31/1989    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1048 408 0.389 8.16 26.0 -0.979
Dimethyl Sulfoxide
0         
50 1053 414 0.393 8.28 26.0 0.000
Test Chemical Acetaldehyde
17         
50 1051 441 0.420 8.82 26.0 6.724
50         
50 1047 599 0.572 11.98 26.0 45.515
167         
50 1047 1370 1.309 27.40 26.0 232.814
500         
50 1050 4044 3.851 80.88 31.0 879.602
1667         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide
 0.125     
50 1042 658 0.631 13.16 26.0 60.615
Cyclophosphamide
 0.5       
10 212 191 0.901 19.10 26.0 129.153
Trend: 69.924        
Probability: 0.000