Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01516-0002-0000-7 |
Chemical Name: | 4-Nitroanthranilic acid |
CASRN: | 619-17-0 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 235278_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Test Failure |
Induced Rat Liver S9 | 1_S9 | Negative |
No Activation | 2 | Questionable |
Induced Rat Liver S9 | 2_S9 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 4-Nitroanthranilic acid | 3000 | 67 | 3 | 0.045 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.045 | 3.0 | 0 | 0.000 | 0.0 |
4000 | 24 | 17 | 0.708 | 13.0 | 17 | 0.708 | 13.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
5000 | 46 | 11 | 0.239 | 11.0 | 9 | 0.196 | 9.0 | 2 | 0.043 | 2.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.25 | 100 | 33 | 0.330 | 27.0 | 22 | 0.220 | 20.0 | 11 | 0.110 | 11.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 1 | 50 | 32 | 0.640 | 50.0 | 27 | 0.540 | 42.0 | 5 | 0.100 | 10.0 | 0 | 0.000 | 0.0 | |
Trend: | 3.128 | 3.678 | 0.232 | ||||||||||||
Probability: | 0.001 | 0.000 | 0.408 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 4-Nitroanthranilic acid | 160 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
300 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
500 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
1000 | 100 | 2 | 0.020 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
1600 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 15 | 100 | 45 | 0.450 | 38.0 | 32 | 0.320 | 27.0 | 13 | 0.130 | 13.0 | 0 | 0.000 | 0.0 |
Trend: | 0.336 | 0.817 | 0.188 | ||||||||||||
Probability: | 0.368 | 0.207 | 0.425 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 4-Nitroanthranilic acid | 1600 | 100 | 3 | 0.030 | 3.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
2200 | 100 | 6 | 0.060 | 6.0 | 4 | 0.040 | 4.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.125 | 100 | 26 | 0.260 | 23.0 | 13 | 0.130 | 13.0 | 12 | 0.120 | 11.0 | 1 | 0.010 | 1.0 |
Mitomycin-C | 0.25 | 50 | 21 | 0.420 | 28.0 | 12 | 0.240 | 16.0 | 9 | 0.180 | 18.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.819 | 1.014 | 2.007 | ||||||||||||
Probability: | 0.034 | 0.155 | 0.022 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 4 | 0.040 | 4.0 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 4-Nitroanthranilic acid | 2200 | 100 | 13 | 0.130 | 9.0 | 7 | 0.070 | 6.0 | 6 | 0.060 | 6.0 | 0 | 0.000 | 0.0 |
2800 | 100 | 18 | 0.180 | 15.0 | 6 | 0.060 | 6.0 | 12 | 0.120 | 11.0 | 0 | 0.000 | 0.0 | ||
3400 | 100 | 50 | 0.500 | 35.0 | 18 | 0.180 | 14.0 | 32 | 0.320 | 26.0 | 1 | 0.010 | 1.0 | ||
4000 | 100 | 21 | 0.210 | 11.0 | 9 | 0.090 | 5.0 | 11 | 0.110 | 7.0 | 1 | 0.010 | 1.0 | ||
Positive Control: | Cyclophosphamide | 15 | 100 | 41 | 0.410 | 32.0 | 23 | 0.230 | 18.0 | 18 | 0.180 | 18.0 | 0 | 0.000 | 0.0 |
Trend: | 3.819 | 1.620 | 3.592 | ||||||||||||
Probability: | 0.000 | 0.053 | 0.000 |