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Study Information
Study Attribute Value
CEBS Accession Number: 002-01494-0012-0000-3
Chemical Name: 4-Chloro-o-phenylenediamine
CASRN: 95-83-0
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 970086_CA
Study Result: Positive (Nonstandard Protocol)

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 06/28/84 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0000
Test Group Dose
(mg/kg)
n Percent Cells w/ Aberrations
(Mean ± SEM)
Pairwise P
Positive Control Dimethylbenzanthracene
200         
8 18.75 ± 3.21 0.0000
Test Chemical 4-Chloro-o-phenylenediamine
100         
8 3.75 ± 1.67 0.0693
 
200         
8 9.50 ± 3.70 0.0000
 
400         
8 8.25 ± 2.94 0.0000
Vehicle Control No Stressor
 0         
8 2.00 ± 1.25 0.0000


Footnotes: IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed