Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01494-0002-0000-2 |
Chemical Name: | 4-Chloro-o-phenylenediamine |
CASRN: | 95-83-0 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 689355_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Weakly Positive* |
Induced Rat Liver S9 | 1_S9 | Negative |
No Activation | 2 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 2.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 4-Chloro-o-phenylenediamine | 1.61 | 200 | 9 | 0.045 | 4.5 | 1 | 0.005 | 1.0 | 8 | 0.040 | 4.0 | 0 | 0.000 | 0.0 |
5.35 | 200 | 12 | 0.060 | 5.0 | 0 | 0.000 | 0.0 | 12 | 0.060 | 5.0 | 0 | 0.000 | 0.0 | ||
16.1 | 200 | 40 | 0.200 | 18.5 | 3 | 0.015 | 2.0 | 37 | 0.185 | 18.0 | 0 | 0.000 | 0.0 | ||
32.2 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 1 | 200 | 66 | 0.330 | 27.0 | 20 | 0.100 | 8.0 | 46 | 0.230 | 20.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 5 | 50 | 50 | 1.000 | 52.0 | 17 | 0.340 | 28.0 | 22 | 0.440 | 32.0 | 11 | 0.220 | 2.0 | |
Trend: | 6.236 | 1.799 | 5.991 | ||||||||||||
Probability: | 0.000 | 0.036 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 3 | 0.015 | 1.5 | 1 | 0.005 | 1.0 | 1 | 0.005 | 1.0 | 1 | 0.005 | 1.0 |
Test Chemical: | 4-Chloro-o-phenylenediamine | 32.2 | 200 | 4 | 0.020 | 2.0 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
108 | 200 | 1 | 0.005 | 0.5 | 1 | 0.005 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
322 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
535 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 50 | 50 | 20 | 0.400 | 26.0 | 11 | 0.220 | 14.0 | 9 | 0.180 | 16.0 | 0 | 0.000 | 0.0 |
Trend: | -1.961 | -1.111 | -1.823 | ||||||||||||
Probability: | 0.975 | 0.867 | 0.966 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 5 | 0.025 | 2.5 | 0 | 0.000 | 0.0 | 5 | 0.025 | 3.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 4-Chloro-o-phenylenediamine | 10.1 | 50 | 71 | 1.420 | 32.0 | 3 | 0.060 | 6.0 | 8 | 0.160 | 16.0 | 60 | 1.200 | 6.0 |
12.7 | 50 | 55 | 1.100 | 42.0 | 4 | 0.080 | 6.0 | 14 | 0.280 | 18.0 | 37 | 0.740 | 10.0 | ||
20.2 | 50 | 87 | 1.740 | 48.0 | 5 | 0.100 | 8.0 | 19 | 0.380 | 28.0 | 63 | 1.260 | 9.0 | ||
Positive Control: | Mitomycin-C | 0.1 | 25 | 92 | 3.680 | 68.0 | 11 | 0.440 | 28.0 | 20 | 0.800 | 32.0 | 61 | 2.440 | 7.0 |
Mitomycin-C | 5 | 10 | 100 | 10.000 | 100.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 100 | 10.000 | 10.0 | |
Trend: | 8.786 | 3.531 | 5.633 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |