Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01494-0001-0000-1 |
Chemical Name: | 4-Chloro-o-phenylenediamine |
CASRN: | 95-83-0 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 689355_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
No Activation | 2 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1044 | 458 | 0.439 | 9.16 | 26.5 | 0.000 |
Test Chemical | 4-Chloro-o-phenylenediamine | 0.51 | 50 | 1051 | 472 | 0.449 | 9.44 | 26.5 | 2.370 |
1.53 | 50 | 1049 | 955 | 0.910 | 19.10 | 26.5 | 107.521 | ||
5.1 | 50 | 1047 | 976 | 0.932 | 19.52 | 26.5 | 112.490 | ||
15.3 | 0 | 0 | 0 | 0.000 | 0.00 | 30.5 | N/A | ||
Positive Control | Mitomycin-C | 0.002 | 50 | 1046 | 700 | 0.669 | 14.00 | 26.5 | 52.546 |
Mitomycin-C | 0.01 | 10 | 209 | 288 | 1.378 | 28.80 | 26.5 | 214.110 | |
Trend: | 16.910 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1049 | 385 | 0.367 | 7.70 | 26.5 | 0.000 |
Test Chemical | 4-Chloro-o-phenylenediamine | 0.76 | 50 | 1035 | 500 | 0.483 | 10.00 | 26.5 | 31.627 |
5.05 | 50 | 1032 | 927 | 0.898 | 18.54 | 26.5 | 144.746 | ||
7.6 | 50 | 1027 | 1264 | 1.231 | 25.28 | 30.5 | 235.345 | ||
10.1 | 0 | 0 | 0 | 0.000 | 0.00 | 30.5 | N/A | ||
Positive Control | Mitomycin-C | 0.002 | 50 | 1040 | 559 | 0.538 | 11.18 | 26.5 | 46.451 |
Mitomycin-C | 0.01 | 10 | 206 | 206 | 1.000 | 20.60 | 26.5 | 172.468 | |
Trend: | 24.754 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1050 | 475 | 0.452 | 9.50 | 25.5 | 0.000 |
Test Chemical | 4-Chloro-o-phenylenediamine | 51 | 50 | 1047 | 584 | 0.558 | 11.68 | 25.5 | 23.300 |
153 | 50 | 1043 | 629 | 0.603 | 12.58 | 25.5 | 33.310 | ||
510 | 50 | 1047 | 794 | 0.758 | 15.88 | 25.5 | 67.637 | ||
1530 | 0 | 0 | 0 | 0.000 | 0.00 | 29.5 | N/A | ||
Positive Control | Cyclophosphamide | 0.5 | 50 | 1051 | 838 | 0.797 | 16.76 | 25.5 | 76.253 |
Cyclophosphamide | 2.5 | 10 | 210 | 444 | 2.114 | 44.40 | 25.5 | 367.368 | |
Trend: | 9.090 | ||||||||
Probability: | 0.000 |