Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01420-0002-0000-1 |
Chemical Name: | 3-Amino-4-ethoxyacetanilide |
CASRN: | 17026-81-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 580234_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 3-Amino-4-ethoxyacetanilide | 1000 | 200 | 6 | 0.030 | 2.5 | 4 | 0.020 | 1.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
1600 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
2500 | 200 | 6 | 0.030 | 3.0 | 2 | 0.010 | 1.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.0625 | 200 | 35 | 0.175 | 15.5 | 14 | 0.070 | 6.5 | 21 | 0.105 | 10.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.25 | 50 | 20 | 0.400 | 32.0 | 15 | 0.300 | 26.0 | 5 | 0.100 | 8.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.277 | -0.014 | 1.814 | ||||||||||||
Probability: | 0.101 | 0.506 | 0.035 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Test Chemical: | 3-Amino-4-ethoxyacetanilide | 1000 | 200 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
1600 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
2500 | 200 | 4 | 0.020 | 2.0 | 1 | 0.005 | 0.5 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 2.5 | 200 | 43 | 0.215 | 18.0 | 12 | 0.060 | 6.0 | 31 | 0.155 | 14.5 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 7.5 | 50 | 30 | 0.600 | 44.0 | 8 | 0.160 | 14.0 | 22 | 0.440 | 34.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.221 | 0.623 | 1.052 | ||||||||||||
Probability: | 0.111 | 0.267 | 0.146 |