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Study Information
Study Attribute Value
CEBS Accession Number: 002-01420-0001-0000-0
Chemical Name: 3-Amino-4-ethoxyacetanilide
CASRN: 17026-81-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 580234_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 09/16/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 415 0.395 8.30 26.0 0.000
Test Chemical 3-Amino-4-ethoxyacetanilide 
16         
 50 1049 473 0.451 9.46 26.0 14.085 
50         
 50 1050 487 0.464 9.74 26.0 17.349 
160         
 50 1049 498 0.475 9.96 26.0 20.114 
500         
 50 1046 572 0.547 11.44 26.0 38.358 
1600         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1046 536 0.512 10.72 26.0 29.651
Mitomycin-C 
 0.005     
 10 210 329 1.567 32.90 26.0 296.386
Trend: 4.901        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 11/11/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 424 0.403 8.48 26.0 0.000
Test Chemical 3-Amino-4-ethoxyacetanilide 
500         
 50 1049 549 0.523 10.98 26.0 29.728 
750         
 50 1050 586 0.558 11.72 26.0 38.339 
1000         
 50 1050 592 0.564 11.84 26.0 39.756 
1600         
 50 1049 676 0.644 13.52 31.5 59.738
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 565 0.538 11.30 26.0 33.382
Mitomycin-C 
 0.005     
 10 210 320 1.524 32.00 26.0 277.718
Trend: 7.376        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/16/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 473 0.451 9.46 26.0 0.000
Test Chemical 3-Amino-4-ethoxyacetanilide 
160         
 50 1051 496 0.472 9.92 26.0 4.563 
500         
 50 1050 515 0.490 10.30 26.0 8.672 
1600         
 50 1049 544 0.519 10.88 26.0 14.901 
2500         
 50 1050 695 0.662 13.90 26.0 46.655
Positive Control Cyclophosphamide 
 0.1       
 50 1047 568 0.543 11.36 26.0 20.199
Cyclophosphamide 
 0.6       
 10 210 256 1.219 25.60 26.0 170.098
Trend: 6.184        
Probability: 0.000