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Study Information
Study Attribute Value
CEBS Accession Number: 002-01381-0002-0000-7
Chemical Name: 3'-Azido-3'-deoxythymidine (AIDS)
CASRN: 30516-87-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 476222_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 01/11/1990    Harvest Time: 14.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: 3'-Azido-3'-deoxythymidine (AIDS)
541         
200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
1163         
200 4 0.020 1.5 1 0.005 0.5 3 0.015 1.0 0 0.000 0.0
2500         
200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.4       
25 22 0.880 52.0 10 0.400 40.0 12 0.480 28.0 0 0.000 0.0
Trend: -0.854 0.000 -1.100  
Probability: 0.803 0.500 0.864  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/11/1990    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
200 6 0.030 3.0 5 0.025 2.5 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide
0         
200 6 0.030 3.0 3 0.015 1.5 3 0.015 1.5 0 0.000 0.0
Test Chemical: 3'-Azido-3'-deoxythymidine (AIDS)
541         
200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
1163         
200 3 0.015 1.5 3 0.015 1.5 0 0.000 0.0 0 0.000 0.0
2500         
200 4 0.020 2.0 3 0.015 1.5 1 0.005 0.5 0 0.000 0.0
Positive Control: Cyclophosphamide
20         
25 31 1.240 48.0 12 0.480 32.0 9 0.360 20.0 10 0.400 4.0
Trend: -0.678 0.450 -1.528  
Probability: 0.751 0.326 0.937