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Study Information
Study Attribute Value
CEBS Accession Number: 002-01381-0001-0000-6
Chemical Name: 3'-Azido-3'-deoxythymidine (AIDS)
CASRN: 30516-87-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 476222_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Positive 
No Activation  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/04/1990    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1048 385 0.367 7.70 26.0 0.000
Negative (Not Specified)
0         
50 1049 363 0.346 7.26 26.0 -5.804
Test Chemical 3'-Azido-3'-deoxythymidine (AIDS)
8.3       
50 1049 715 0.682 14.30 26.0 85.537
25         
50 1049 918 0.875 18.36 26.0 138.214
83         
25 525 538 1.025 21.52 26.0 178.948
250         
0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C
 0.001     
50 1047 687 0.656 13.74 26.0 78.612
Mitomycin-C
 0.004     
10 208 187 0.899 18.70 26.0 144.725
Trend: 16.813        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 01/23/1990    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1049 397 0.378 7.94 26.0 3.385
Dimethyl Sulfoxide
0         
50 1049 384 0.366 7.68 26.0 0.000
Test Chemical 3'-Azido-3'-deoxythymidine (AIDS)
8.3       
50 1049 564 0.538 11.28 26.0 46.875
25         
50 1047 645 0.616 12.90 26.0 68.290
83         
25 522 481 0.921 19.24 26.0 151.721
250         
0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C
 0.001     
50 1051 532 0.506 10.64 26.0 38.278
Mitomycin-C
 0.004     
10 210 186 0.886 18.60 26.0 141.957
Trend: 13.577        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/04/1990    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1044 402 0.385 8.04 26.0 5.587
Dimethyl Sulfoxide
0         
50 1042 380 0.365 7.60 26.0 0.000
Test Chemical 3'-Azido-3'-deoxythymidine (AIDS)
250         
50 1050 443 0.422 8.86 26.0 15.691
833         
50 1049 479 0.457 9.58 26.0 25.211
2500         
50 1047 551 0.526 11.02 26.0 44.308
Positive Control Cyclophosphamide
 0.125     
50 1049 670 0.639 13.40 26.0 75.139
Cyclophosphamide
 0.5       
10 210 204 0.971 20.40 26.0 166.376
Trend: 5.632        
Probability: 0.000