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Study Information
Study Attribute Value
CEBS Accession Number: 002-01338-0001-0000-8
Chemical Name: 2-Hydroxy-4-methoxybenzophenone
CASRN: 131-57-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 059393_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Questionable 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 10/17/1989    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1036 407 0.393 8.14 26.0 3.904
Dimethyl Sulfoxide 
0         
 50 1050 397 0.378 7.94 31.0 0.000
Test Chemical 2-Hydroxy-4-methoxybenzophenone 
1.7       
 50 1038 390 0.376 7.80 26.0 -0.628 
5         
 50 1043 439 0.421 8.78 26.0 11.321 
17         
 50 1042 464 0.445 9.28 31.0 17.774 
50         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1046 680 0.650 13.60 26.0 71.940
Mitomycin-C 
 0.004     
 10 209 203 0.971 20.30 26.0 156.891
Trend: 2.799        
Probability: 0.003        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/17/1989    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1047 368 0.351 7.36 26.0 -4.728
Dimethyl Sulfoxide 
0         
 50 1049 387 0.369 7.74 26.0 0.000
Test Chemical 2-Hydroxy-4-methoxybenzophenone 
5         
 50 1042 464 0.445 9.28 26.0 20.702 
17         
 50 1045 623 0.596 12.46 26.0 61.598 
50         
 50 1045 626 0.599 12.52 26.0 62.376 
167         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.125     
 50 1044 579 0.555 11.58 26.0 50.329
Cyclophosphamide 
 0.5       
 10 210 244 1.162 24.40 26.0 214.945
Trend: 8.653        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 11/15/1989    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 383 0.365 7.66 26.0 0.000
Negative (Not Specified) 
0         
 50 1052 419 0.398 8.38 26.0 9.191
Test Chemical 2-Hydroxy-4-methoxybenzophenone 
12.5       
 50 1054 547 0.519 10.94 26.0 42.278 
25         
 50 1046 715 0.684 14.30 26.0 87.398 
50         
 50 1048 701 0.669 14.02 26.0 83.378 
100         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.125     
 50 1049 609 0.581 12.18 26.0 59.159
Cyclophosphamide 
 0.5       
 10 212 245 1.156 24.50 26.0 216.826
Trend: 10.434        
Probability: 0.000