Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01324-0002-0000-4 |
Chemical Name: | 2-Ethylhexanoic acid |
CASRN: | 149-57-5 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 631517_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Weakly Positive* |
Induced Rat Liver S9 | 2_S9 | Weakly Positive* |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | 2-Ethylhexanoic acid | 1030 | 100 | 5 | 0.050 | 5.0 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 |
1500 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
2060 | 100 | 5 | 0.050 | 4.0 | 0 | 0.000 | 0.0 | 5 | 0.050 | 4.0 | 0 | 0.000 | 0.0 | ||
2530 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.025 | 100 | 14 | 0.140 | 12.0 | 6 | 0.060 | 5.0 | 6 | 0.060 | 6.0 | 2 | 0.020 | 1.0 |
Mitomycin-C | 0.0625 | 25 | 7 | 0.280 | 24.0 | 4 | 0.160 | 12.0 | 1 | 0.040 | 4.0 | 2 | 0.080 | 8.0 | |
Trend: | 0.081 | -1.354 | 0.965 | ||||||||||||
Probability: | 0.468 | 0.912 | 0.167 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | 2-Ethylhexanoic acid | 2700 | 100 | 3 | 0.030 | 3.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
3000 | 100 | 7 | 0.070 | 2.0 | 4 | 0.040 | 2.0 | 3 | 0.030 | 1.0 | 0 | 0.000 | 0.0 | ||
3300 | 100 | 9 | 0.090 | 3.0 | 4 | 0.040 | 2.0 | 5 | 0.050 | 1.0 | 0 | 0.000 | 0.0 | ||
3500 | 25 | 26 | 1.040 | 48.0 | 10 | 0.400 | 32.0 | 15 | 0.600 | 32.0 | 1 | 0.040 | 1.0 | ||
4000 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 2.5 | 100 | 6 | 0.060 | 6.0 | 4 | 0.040 | 4.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 12.5 | 25 | 25 | 1.000 | 40.0 | 17 | 0.680 | 36.0 | 8 | 0.320 | 24.0 | 0 | 0.000 | 0.0 | |
Trend: | 5.081 | 4.082 | 4.297 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Negative (Not Specified) | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | 2-Ethylhexanoic acid | 2250 | 100 | 4 | 0.040 | 2.0 | 3 | 0.030 | 2.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
2530 | 100 | 8 | 0.080 | 6.0 | 2 | 0.020 | 2.0 | 6 | 0.060 | 4.0 | 0 | 0.000 | 0.0 | ||
3000 | 100 | 54 | 0.540 | 30.0 | 27 | 0.270 | 19.0 | 26 | 0.260 | 17.0 | 1 | 0.010 | 1.0 | ||
3470 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 2.5 | 100 | 3 | 0.030 | 2.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 2.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 12.5 | 50 | 10 | 0.200 | 14.0 | 2 | 0.040 | 4.0 | 8 | 0.160 | 10.0 | 0 | 0.000 | 0.0 | |
Trend: | 7.074 | 5.697 | 5.039 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |